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SSX1 (SSX family member 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.
Could act as a modulator of transcription. Plays a role in spermatogenesis.
Open Targets scores its association with cancer at 0.69 (direct and indirect evidence; datatypes literature 0.70, genetic association 0.56, somatic mutation 0.98).
In plain words · SSX1 (SSX family member 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.
SSX1 (SSX family member 1) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.
Could act as a modulator of transcription. Plays a role in spermatogenesis.
No product in this corpus aims at SSX1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1995. Earliest sequence paper UniProt cites for the protein: Crew A.J. et al, EMBO J, 1995, "Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma". Source.
Sources: HGNC HGNC:11335 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16384 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000126752 (association with cancer (MONDO_0004992) 0.69; per-cancer scores at or above 0.5: sarcoma 0.68, synovial sarcoma 0.60 (GraphQL API, CC0))
Could act as a modulator of transcription. Plays a role in spermatogenesis. Location: Cytoplasm, cytoskeleton, flagellum axoneme (UniProt). Locus Xp11.23 (HGNC).
Query for this target: (TITLE:"SSX1" OR ABSTRACT:"SSX1" OR TITLE:"SSX family member 1" OR ABSTRACT:"SSX family member 1" OR TITLE:"CT5.1" OR ABSTRACT:"CT5.1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SSX1, not a curated reading list.
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST).