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SS18 (SS18 subunit of BAF chromatin remodeling complex) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.
Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.21, somatic mutation 0.97).
In plain words · SS18 (SS18 subunit of BAF chromatin remodeling complex) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.
SS18 (SS18 subunit of BAF chromatin remodeling complex) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Sarcomas and Synovial sarcoma.
Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation.
No product in this corpus aims at SS18 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1994. Earliest sequence paper UniProt cites for the protein: Clark et al, Nat. Genet, 1994, "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma". Source.
Sources: HGNC HGNC:11340 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q15532 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000141380 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: sarcoma 0.61, synovial sarcoma 0.53 (GraphQL API, CC0))
Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation. Component of SWI/SNF chromatin remodeling subcomplex GBAF that carries out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Location: Nucleus (UniProt). Locus 18q11.2 (HGNC).
Query for this target: (TITLE:"SS18" OR ABSTRACT:"SS18" OR TITLE:"SS18 subunit of BAF chromatin remodeling complex" OR ABSTRACT:"SS18 subunit of BAF chromatin remodeling complex" OR TITLE:"SMARCL1" OR ABSTRACT:"SMARCL1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SS18, not a curated reading list.
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST).
Shares Synovial sarcoma, Sarcomas (soft tissue, bone, GIST).