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RHOBTB2 (Rho-related BTB domain-containing protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.67, somatic mutation 0.23).
In plain words · RHOBTB2 (Rho-related BTB domain-containing protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
RHOBTB2 (Rho-related BTB domain-containing protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g.
No product in this corpus aims at RHOBTB2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1998. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:18756 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BYZ6 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000008853 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation. Required for MSI2 ubiquitination and degradation. Locus 8p21.3 (HGNC).
Query for this target: (TITLE:"RHOBTB2" OR ABSTRACT:"RHOBTB2" OR TITLE:"Rho related BTB domain containing 2" OR ABSTRACT:"Rho related BTB domain containing 2" OR TITLE:"Rho-related BTB domain-containing protein 2" OR ABSTRACT:"Rho-related BTB domain-containing protein 2" OR TITLE:"KIAA0717" OR ABSTRACT:"KIAA0717" OR TITLE:"DBC2" OR ABSTRACT:"DBC2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RHOBTB2, not a curated reading list.