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RHOBTB2 (Rho-related BTB domain-containing protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation. Required for MSI2 ubiquitination and degradation. Locus 8p21.3 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"RHOBTB2" OR ABSTRACT:"RHOBTB2" OR TITLE:"Rho related BTB domain containing 2" OR ABSTRACT:"Rho related BTB domain containing 2" OR TITLE:"Rho-related BTB domain-containing protein 2" OR ABSTRACT:"Rho-related BTB domain-containing protein 2" OR TITLE:"KIAA0717" OR ABSTRACT:"KIAA0717" OR TITLE:"DBC2" OR ABSTRACT:"DBC2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RHOBTB2, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/rhobtb2.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/rhobtb2.json. Licence CC BY-NC 4.0.