{"entity":{"id":"rhobtb2","kind":"target","name":"RHOBTB2","aka":["Rho related BTB domain containing 2","Rho-related BTB domain-containing protein 2","KIAA0717","DBC2"],"tldr":"RHOBTB2 (Rho-related BTB domain-containing protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation.\n\nOpen Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, genetic association 0.67, somatic mutation 0.23).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18756","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18756"},{"label":"UniProt Q9BYZ6","url":"https://www.uniprot.org/uniprotkb/Q9BYZ6/entry"},{"label":"NCBI Gene 23221","url":"https://www.ncbi.nlm.nih.gov/gene/23221"},{"label":"Ensembl ENSG00000008853","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000008853"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RHOBTB2","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:18756","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18756","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9BYZ6","url":"https://www.uniprot.org/uniprotkb/Q9BYZ6/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000008853","url":"https://platform.opentargets.org/target/ENSG00000008853/associations","note":"association with cancer (MONDO_0004992) 0.56;  (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:18756","ensembl":"ENSG00000008853","uniprot":"Q9BYZ6","entrez":"23221","firstDescribed":1998,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1998, \"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/9872452/","biology":"Regulator of cell proliferation and apoptosis. It likely functions as a substrate-adapter that recruits key substrates, e.g. MSI2, to CUL3-based ubiquitin ligase complexes for degradation. Required for MSI2 ubiquitination and degradation. Locus 8p21.3 (HGNC).","whereFound":[],"targetClass":"enzyme","prevalence":[]},"route":"/targets/rhobtb2/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}