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RAD51 (DNA repair protein RAD51 homolog 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
Homologous DNA recombinase that catalyses strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA (ssDNA) in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyses the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template.
Open Targets scores its association with cancer at 0.73 (direct and indirect evidence; datatypes genetic literature 0.61, affected pathway 0.87, literature 0.99, genetic association 0.70, somatic mutation 0.49).
In plain words · RAD51 (DNA repair protein RAD51 homolog 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
RAD51 (DNA repair protein RAD51 homolog 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
Homologous DNA recombinase that catalyses strand exchange, a key step in DNA repair through homologous recombination (HR).
No product in this corpus aims at RAD51 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1993. Earliest sequence paper UniProt cites for the protein: Shinohara et al, Nat. Genet, 1993, "Cloning of human, mouse and fission yeast recombination genes homologous to RAD51 and recA". Source.
Sources: HGNC HGNC:9817 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q06609 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000051180 (association with cancer (MONDO_0004992) 0.73; per-cancer scores at or above 0.5: breast cancer 0.64 (GraphQL API, CC0))
Homologous DNA recombinase that catalyses strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA (ssDNA) in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyses the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. RAD51 targeting to ssDNA promotes removal of replication protein-A (RPA) from ssDNA and stabilisation of RAD51-ssDNA filaments by blocking ATP hydrolysis. Nucleosomal DNA is peeled from the histone surface by the RAD51 filament. Recruited to resolve stalled replication forks during replication stress. Location: Chromosome; Nucleus; Cytoplasm; Cytoplasm, perinuclear region (UniProt). Locus 15q15.1 (HGNC).
Query for this target: (TITLE:"RAD51" OR ABSTRACT:"RAD51" OR TITLE:"RAD51 recombinase" OR ABSTRACT:"RAD51 recombinase" OR TITLE:"DNA repair protein RAD51 homolog 1" OR ABSTRACT:"DNA repair protein RAD51 homolog 1" OR TITLE:"HsRad51" OR ABSTRACT:"HsRad51" OR TITLE:"HsT16930" OR ABSTRACT:"HsT16930" OR TITLE:"BRCC5" OR ABSTRACT:"BRCC5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RAD51, not a curated reading list.
Shares Double-strand break repair: HR versus end joining, Open Targets Platform.
Shares Double-strand break repair: HR versus end joining, Open Targets Platform.
Shares Double-strand break repair: HR versus end joining, Breast cancer (all types), Open Targets Platform.
Shares Double-strand break repair: HR versus end joining, Breast cancer (all types), Open Targets Platform.