Loading
RAD51 (DNA repair protein RAD51 homolog 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Homologous DNA recombinase that catalyses strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA (ssDNA) in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyses the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. RAD51 targeting to ssDNA promotes removal of replication protein-A (RPA) from ssDNA and stabilisation of RAD51-ssDNA filaments by blocking ATP hydrolysis. Nucleosomal DNA is peeled from the histone surface by the RAD51 filament. Recruited to resolve stalled replication forks during replication stress. Location: Chromosome; Nucleus; Cytoplasm; Cytoplasm, perinuclear region (UniProt). Locus 15q15.1 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"RAD51" OR ABSTRACT:"RAD51" OR TITLE:"RAD51 recombinase" OR ABSTRACT:"RAD51 recombinase" OR TITLE:"DNA repair protein RAD51 homolog 1" OR ABSTRACT:"DNA repair protein RAD51 homolog 1" OR TITLE:"HsRad51" OR ABSTRACT:"HsRad51" OR TITLE:"HsT16930" OR ABSTRACT:"HsT16930" OR TITLE:"BRCC5" OR ABSTRACT:"BRCC5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RAD51, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/rad51.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/rad51.json. Licence CC BY-NC 4.0.