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LIG4 (DNA ligase 4) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Catalyses the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed. Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.88, animal model 0.51, genetic association 0.44, genetic literature 0.76).
In plain words · LIG4 (DNA ligase 4) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
LIG4 (DNA ligase 4) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination.
No product in this corpus aims at LIG4 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1995. Earliest sequence paper UniProt cites for the protein: Wei Y.-F. et al, Mol. Cell. Biol, 1995, "Molecular cloning and expression of human cDNAs encoding a novel DNA ligase IV and DNA ligase III, an enzyme active in DNA repair and recombination". Source.
Sources: HGNC HGNC:6601 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P49917 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000174405 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
DNA ligase involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination. Catalyses the NHEJ ligation step of the broken DNA during DSB repair by resealing the DNA breaks after the gap filling is completed. Joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. LIG4 is mechanistically flexible: it can ligate nicks as well as compatible DNA overhangs alone, while in the presence of XRCC4, it can ligate ends with 2-nucleotides (nt) microhomology and 1-nt gaps. Forms a subcomplex with XRCC4; the LIG4-XRCC4 subcomplex is responsible for the NHEJ ligation step and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. Location: Nucleus (UniProt). Locus 13q33.3 (HGNC).
Query for this target: (TITLE:"LIG4" OR ABSTRACT:"LIG4" OR TITLE:"DNA ligase 4" OR ABSTRACT:"DNA ligase 4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about LIG4, not a curated reading list.
Shares Double-strand break repair: HR versus end joining, Open Targets Platform.
Shares Double-strand break repair: HR versus end joining, Open Targets Platform.
Shares Double-strand break repair: HR versus end joining, Open Targets Platform.
Shares Double-strand break repair: HR versus end joining, Open Targets Platform.