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RABL3 (Rab-like protein 3) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.
Small GTPase required for KRAS signalling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases. Required for lymphocyte development and function.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.46, genetic association 0.67, genetic literature 0.61).
In plain words · RABL3 (Rab-like protein 3) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.
RABL3 (Rab-like protein 3) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.
Small GTPase required for KRAS signalling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases.
No product in this corpus aims at RABL3 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RABL3: RNA low tissue specificity; no normal tissue stained high; highest cancer staining breast cancer (1 of 10 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Pancreatic ductal adenocarcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas RABL3 tissue; Open Targets ENSG00000144840 associations
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:18072 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q5HYI8 (protein name, function text, keywords and locations (REST API)); CIViC gene RABL3 (1 evidence items, 0 assertions, 1 variants; diseases: Pancreatic Cancer (GraphQL API, CC0)); Open Targets ENSG00000144840 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0))
Small GTPase required for KRAS signalling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases. Required for lymphocyte development and function. Not required for myeloid cell development. Interacts with Rab11 to promote ciliary vesicle formation at the mother centriole, thereby regulating early ciliogenesis. The GTP-binding capacity of RABL3 is essential for ciliogenesis. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Golgi apparatus (UniProt). Locus 3q13.33 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high.
Medium only: cervical cancer, colorectal cancer, head and neck cancer, liver cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"RABL3" OR ABSTRACT:"RABL3" OR TITLE:"RAB, member of RAS oncogene family like 3" OR ABSTRACT:"RAB, member of RAS oncogene family like 3" OR TITLE:"Rab-like protein 3" OR ABSTRACT:"Rab-like protein 3" OR TITLE:"MGC23920" OR ABSTRACT:"MGC23920") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RABL3, not a curated reading list.