{"entity":{"id":"rabl3","kind":"target","name":"RABL3","aka":["RAB, member of RAS oncogene family like 3","Rab-like protein 3","MGC23920"],"tldr":"RABL3 (Rab-like protein 3) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Pancreatic ductal adenocarcinoma.","summary":"Small GTPase required for KRAS signalling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases. Required for lymphocyte development and function.\n\nCIViC holds 1 clinical evidence item and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.46, genetic association 0.67, genetic literature 0.61).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:18072","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18072"},{"label":"UniProt Q5HYI8","url":"https://www.uniprot.org/uniprotkb/Q5HYI8/entry"},{"label":"NCBI Gene 285282","url":"https://www.ncbi.nlm.nih.gov/gene/285282"},{"label":"Ensembl ENSG00000144840","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000144840"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["pancreatic"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 1 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"RABL3","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:18072","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18072","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q5HYI8","url":"https://www.uniprot.org/uniprotkb/Q5HYI8/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene RABL3","url":"https://civicdb.org/features/21380","note":"1 evidence items, 0 assertions, 1 variants; diseases: Pancreatic Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000144840","url":"https://platform.opentargets.org/target/ENSG00000144840/associations","note":"association with cancer (MONDO_0004992) 0.60;  (GraphQL API, CC0)"}],"specificity":"broadly-expressed","distribution":"one-type","specificityNote":"Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA RABL3: RNA low tissue specificity; no normal tissue stained high; highest cancer staining breast cancer (1 of 10 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Pancreatic ductal adenocarcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas RABL3 tissue","url":"https://www.proteinatlas.org/ENSG00000144840-RABL3/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000144840 associations","url":"https://platform.opentargets.org/target/ENSG00000144840/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:18072","ensembl":"ENSG00000144840","uniprot":"Q5HYI8","entrez":"285282","firstDescribed":2004,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, \"Complete sequencing and characterization of 21,243 full-length human cDNAs\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/14702039/","biology":"Small GTPase required for KRAS signalling regulation and modulation of cell proliferation. Regulator of KRAS prenylation, and probably prenylation of other small GTPases. Required for lymphocyte development and function. Not required for myeloid cell development. Interacts with Rab11 to promote ciliary vesicle formation at the mother centriole, thereby regulating early ciliogenesis. The GTP-binding capacity of RABL3 is essential for ciliogenesis. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Golgi apparatus (UniProt). Locus 3q13.33 (HGNC).","whereFound":["Pancreatic ductal adenocarcinoma: CIViC evidence names this disease"],"targetClass":"enzyme","prevalence":[]},"route":"/targets/rabl3/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"pancreatic","kind":"cancer","name":"Pancreatic ductal adenocarcinoma","route":"/cancers/pancreatic/"}]}}