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NCOR1 (Nuclear receptor corepressor 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Prostate cancer, Lung cancer and 5 more.
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6.
Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.23, somatic mutation 0.96). IntOGen calls it a driver in 18 cohorts (3 activating, 15 loss-of-function), covering Acute Lymphoblastic Leukaemia, Bladder Urothelial Carcinoma, Invasive Breast Carcinoma, Cholangiocarcinoma, Diffuse Large B-Cell Lymphoma, NOS, Head and Neck Squamous Cell Carcinoma and others.
In plain words · NCOR1 (Nuclear receptor corepressor 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Prostate cancer, Lung cancer and 5 more.
NCOR1 (Nuclear receptor corepressor 1) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Breast cancer, Prostate cancer, Lung cancer and 5 more.
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors.
No product in this corpus aims at NCOR1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1998. Earliest sequence paper UniProt cites for the protein: Wang et al, Proc. Natl. Acad. Sci. U.S.A, 1998, "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Source.
Sources: HGNC HGNC:7672 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O75376 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000141027 (association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: colorectal cancer 0.55, melanoma 0.52, skin cancer 0.55, breast cancer 0.70, lung cancer 0.59, biliary tract cancer 0.51 (GraphQL API, CC0)); IntOGen NCOR1 (driver in 18 cohorts (Act 3, LoF 15); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signalling and androgen-induced cell proliferation. Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression. The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver. Location: Nucleus (UniProt). Locus 17p12-p11.2 (HGNC).
Query for this target: (TITLE:"NCOR1" OR ABSTRACT:"NCOR1" OR TITLE:"nuclear receptor corepressor 1" OR ABSTRACT:"nuclear receptor corepressor 1" OR TITLE:"Nuclear receptor corepressor 1" OR ABSTRACT:"Nuclear receptor corepressor 1" OR TITLE:"N-CoR" OR ABSTRACT:"N-CoR" OR TITLE:"hCIT529I10" OR ABSTRACT:"hCIT529I10" OR TITLE:"TRAC1" OR ABSTRACT:"TRAC1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NCOR1, not a curated reading list.
Shares Mesothelioma, Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Mesothelioma, Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Mesothelioma, Skin cancer (all types), IntOGen, Head and neck squamous cell carcinoma.
Shares Mesothelioma, Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Mesothelioma, Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Mesothelioma, Skin cancer (all types), IntOGen, Lung cancer (all types).
Shares Mesothelioma, Skin cancer (all types), IntOGen, Open Targets Platform.
Shares Mesothelioma, IntOGen, Head and neck squamous cell carcinoma, Breast cancer (all types).