Loading
FAT4 (Protocadherin Fat 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Colorectal cancer, Hepatocellular carcinoma and 5 more.
Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation.
Open Targets scores its association with cancer at 0.72 (direct and indirect evidence; datatypes literature 0.97, animal model 0.39, genetic association 0.36, somatic mutation 0.90). IntOGen calls it a driver in 37 cohorts (24 activating, 12 loss-of-function), covering Adrenocortical Carcinoma, Acute Lymphoblastic Leukaemia, Acute Myeloid Leukaemia, Anal Squamous Cell Carcinoma, Basal Cell Carcinoma, Invasive Breast Carcinoma and others.
In plain words · FAT4 (Protocadherin Fat 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Colorectal cancer, Hepatocellular carcinoma and 5 more.
FAT4 (Protocadherin Fat 4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Prostate cancer, Colorectal cancer, Hepatocellular carcinoma and 5 more.
Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation.
No product in this corpus aims at FAT4 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2003. Earliest sequence paper UniProt cites for the protein: Ohira et al, Cancer Lett, 2003, "Neuroblastoma oligo-capping cDNA project: toward the understanding of the genesis and biology of neuroblastoma". Source.
Sources: HGNC HGNC:23109 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6V0I7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000196159 (association with cancer (MONDO_0004992) 0.72; per-cancer scores at or above 0.5: colorectal cancer 0.62, gastric cancer 0.56, oesophageal cancer 0.50, ovarian cancer 0.52, melanoma 0.60, non-Hodgkin lymphoma 0.52 (GraphQL API, CC0)); IntOGen FAT4 (driver in 37 cohorts (Act 24, LoF 12); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation. Location: Membrane (UniProt). Locus 4q28.1 (HGNC).
Query for this target: (TITLE:"FAT4" OR ABSTRACT:"FAT4" OR TITLE:"FAT atypical cadherin 4" OR ABSTRACT:"FAT atypical cadherin 4" OR TITLE:"Protocadherin Fat 4" OR ABSTRACT:"Protocadherin Fat 4" OR TITLE:"CDHF14" OR ABSTRACT:"CDHF14" OR TITLE:"FAT-J" OR ABSTRACT:"FAT-J" OR TITLE:"CDHR11" OR ABSTRACT:"CDHR11") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FAT4, not a curated reading list.
Shares Mesothelioma, Oesophageal cancer, Skin cancer (all types), Hepatocellular carcinoma.
Shares Mesothelioma, Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Mesothelioma, Oesophageal cancer, Hepatocellular carcinoma, IntOGen.
Shares Mesothelioma, Oesophageal cancer, Skin cancer (all types), IntOGen.
Shares Mesothelioma, Skin cancer (all types), IntOGen, Breast cancer (all types).
Shares Mesothelioma, Skin cancer (all types), IntOGen, Open Targets Platform.
Shares Mesothelioma, Hepatocellular carcinoma, IntOGen, Breast cancer (all types).
Shares Mesothelioma, IntOGen, Gastric & gastro-oesophageal junction cancer, Colorectal cancer.