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HOXB13 (Homeobox protein Hox-B13) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Gastric & gastro-oesophageal junction cancer.
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.99, genetic association 0.86, somatic mutation 0.30, animal model 0.38). In OnCo, 1 product record names it (Breast Cancer Index).
In plain words · HOXB13 (Homeobox protein Hox-B13) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Gastric & gastro-oesophageal junction cancer.
HOXB13 (Homeobox protein Hox-B13) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Gastric & gastro-oesophageal junction cancer.
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA.
No product in this corpus aims at HOXB13 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Tumour-associated overexpression: HPA finds the RNA cancer enriched in cancer (Prostate Adenocarcinoma (TCGA)) and group enriched in normal intestine, prostate, so the tumour and the normal tissue it comes from share the target and the medicine relies on the difference in level. HPA HOXB13: RNA group enriched (intestine 39 nTPM, prostate 77 nTPM); high antibody staining in 3 normal tissues; highest cancer staining prostate cancer (6 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Prostate cancer, Gastric & gastro-oesophageal junction cancer); Open Targets associates it with 2 specific cancer types at or above 0.5 (Familial prostate cancer, gastric cancer). (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas HOXB13 tissue; Human Protein Atlas HOXB13 pathology; Open Targets ENSG00000159184 associations
First described 1996. Earliest sequence paper UniProt cites for the protein: Zeltser L.M. et al, Development, 1996, "Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity". Source.
Sources: HGNC HGNC:5112 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92826 (protein name, function text, keywords and locations (REST API)); CIViC gene HOXB13 (2 evidence items, 0 assertions, 1 variants; diseases: Prostate Cancer (GraphQL API, CC0)); Open Targets ENSG00000159184 (association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: gastric cancer 0.52, prostate cancer 0.74 (GraphQL API, CC0))
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA. Location: Nucleus (UniProt). Locus 17q21.32 (HGNC).
RNA: group enriched (intestine 39 nTPM, prostate 77 nTPM), detected in some normal tissues.
RNA cancer enriched: Prostate Adenocarcinoma 297 pTPM.
Medium only: stomach cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"HOXB13" OR ABSTRACT:"HOXB13" OR TITLE:"homeobox B13" OR ABSTRACT:"homeobox B13" OR TITLE:"Homeobox protein Hox-B13" OR ABSTRACT:"Homeobox protein Hox-B13") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HOXB13, not a curated reading list.