{"entity":{"id":"hoxb13","kind":"target","name":"HOXB13","aka":["homeobox B13","Homeobox protein Hox-B13"],"tldr":"HOXB13 (Homeobox protein Hox-B13) is a protein that switches other genes on and off. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer and Gastric & gastro-oesophageal junction cancer.","summary":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA.\n\nCIViC holds 2 clinical evidence items and 0 assertions across 1 variant. Open Targets scores its association with cancer at 0.76 (direct and indirect evidence; datatypes genetic literature 0.61, literature 0.99, genetic association 0.86, somatic mutation 0.30, animal model 0.38). In OnCo, 1 product record names it (Breast Cancer Index).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:5112","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5112"},{"label":"UniProt Q92826","url":"https://www.uniprot.org/uniprotkb/Q92826/entry"},{"label":"NCBI Gene 10481","url":"https://www.ncbi.nlm.nih.gov/gene/10481"},{"label":"Ensembl ENSG00000159184","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000159184"}],"tags":["cancer-genes-wave"],"related":["civic","open-targets"],"cancers":["prostate","gastric"],"sections":[],"technologies":[],"targets":[],"drugs":["breast-cancer-index"],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 2 clinical evidence items on its variants. Evidence tier \"clinical-evidence\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"HOXB13","role":["biomarker"],"evidenceTier":"clinical-evidence","sources":[{"label":"HGNC HGNC:5112","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:5112","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q92826","url":"https://www.uniprot.org/uniprotkb/Q92826/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"CIViC gene HOXB13","url":"https://civicdb.org/features/8351","note":"2 evidence items, 0 assertions, 1 variants; diseases: Prostate Cancer (GraphQL API, CC0)"},{"label":"Open Targets ENSG00000159184","url":"https://platform.opentargets.org/target/ENSG00000159184/associations","note":"association with cancer (MONDO_0004992) 0.76; per-cancer scores at or above 0.5: gastric cancer 0.52, prostate cancer 0.74 (GraphQL API, CC0)"}],"specificity":"tumour-associated","distribution":"few-types","specificityNote":"Tumour-associated overexpression: HPA finds the RNA cancer enriched in cancer (Prostate Adenocarcinoma (TCGA)) and group enriched in normal intestine, prostate, so the tumour and the normal tissue it comes from share the target and the medicine relies on the difference in level. HPA HOXB13: RNA group enriched (intestine 39 nTPM, prostate 77 nTPM); high antibody staining in 3 normal tissues; highest cancer staining prostate cancer (6 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Prostate cancer, Gastric & gastro-oesophageal junction cancer); Open Targets associates it with 2 specific cancer types at or above 0.5 (Familial prostate cancer, gastric cancer). (Rule 7 of scripts/fetch-target-specificity.ts.)","specificitySources":[{"label":"Human Protein Atlas HOXB13 tissue","url":"https://www.proteinatlas.org/ENSG00000159184-HOXB13/tissue","note":"RNA tissue and blood lineage specificity, normal tissue antibody staining (version 25.1, CC BY-SA 3.0)"},{"label":"Human Protein Atlas HOXB13 pathology","url":"https://www.proteinatlas.org/ENSG00000159184-HOXB13/pathology","note":"patients per staining level per cancer type (version 25.1, CC BY-SA 3.0)"},{"label":"Open Targets ENSG00000159184 associations","url":"https://platform.opentargets.org/target/ENSG00000159184/associations","note":"cancer associations at or above 0.5 (CC0)"}],"hgnc":"HGNC:5112","ensembl":"ENSG00000159184","uniprot":"Q92826","entrez":"10481","firstDescribed":1996,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Zeltser L.M. et al, Development, 1996, \"Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/8756292/","biology":"Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA. Location: Nucleus (UniProt). Locus 17q21.32 (HGNC).","whereFound":["Prostate cancer: Open Targets association 0.74 with prostate cancer (MONDO_0008315); CIViC evidence names this disease","Gastric & gastro-oesophageal junction cancer: Open Targets association 0.52 with gastric cancer (MONDO_0001056)"],"targetClass":"transcription","prevalence":[]},"route":"/targets/hoxb13/","neighbours":{"collection":[{"id":"civic","kind":"collection","name":"CIViC","route":"/collections/civic/"},{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}],"cancer":[{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"},{"id":"prostate","kind":"cancer","name":"Prostate cancer","route":"/cancers/prostate/"}],"drug":[{"id":"breast-cancer-index","kind":"drug","name":"Breast Cancer Index","route":"/drugs/breast-cancer-index/"}]}}