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HEY1 (Hairy/enhancer-of-split related with YRPW motif protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas and Chondrosarcoma.
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signalling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, somatic mutation 0.95).
In plain words · HEY1 (Hairy/enhancer-of-split related with YRPW motif protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas and Chondrosarcoma.
HEY1 (Hairy/enhancer-of-split related with YRPW motif protein 1) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas and Chondrosarcoma.
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signalling required for cardiovascular development.
No product in this corpus aims at HEY1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1999. Earliest sequence paper UniProt cites for the protein: Kokubo et al, Biochem. Biophys. Res. Commun, 1999, "Identification and expression of a novel family of bHLH cDNAs related to Drosophila hairy and enhancer of split". Source.
Sources: HGNC HGNC:4880 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y5J3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164683 (association with cancer (MONDO_0004992) 0.60; per-cancer scores at or above 0.5: sarcoma 0.54, chondrosarcoma 0.52 (GraphQL API, CC0))
Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3'. Downstream effector of Notch signalling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3. Location: Nucleus (UniProt). Locus 8q21.13 (HGNC).
Query for this target: (TITLE:"HEY1" OR ABSTRACT:"HEY1" OR TITLE:"hes related family bHLH transcription factor with YRPW motif 1" OR ABSTRACT:"hes related family bHLH transcription factor with YRPW motif 1" OR TITLE:"Hairy/enhancer-of-split related with YRPW motif protein 1" OR ABSTRACT:"Hairy/enhancer-of-split related with YRPW motif protein 1" OR TITLE:"HESR-1" OR ABSTRACT:"HESR-1" OR TITLE:"CHF2" OR ABSTRACT:"CHF2" OR TITLE:"HESR1" OR ABSTRACT:"HESR1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about HEY1, not a curated reading list.
Shares Chondrosarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Chondrosarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.