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EXT1 (Exostosin-1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas, Breast cancer, Ovarian cancer and 2 more.
Glycosyltransferase forming with EXT2 the heterodimeric heparan sulfate polymerase which catalyses the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity.
Open Targets scores its association with cancer at 0.84 (direct and indirect evidence; datatypes genetic literature 0.81, affected pathway 0.30, literature 0.94, genetic association 0.75, somatic mutation 0.89, animal model 0.72).
In plain words · EXT1 (Exostosin-1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas, Breast cancer, Ovarian cancer and 2 more.
EXT1 (Exostosin-1) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Sarcomas, Breast cancer, Ovarian cancer and 2 more.
Glycosyltransferase forming with EXT2 the heterodimeric heparan sulfate polymerase which catalyses the elongation of the heparan sulfate glycan backbone.
No product in this corpus aims at EXT1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1995. Earliest sequence paper UniProt cites for the protein: Ahn et al, Nat. Genet, 1995, "Cloning of the putative tumour suppressor gene for hereditary multiple exostoses (EXT1)". Source.
Sources: HGNC HGNC:3512 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q16394 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000182197 (association with cancer (MONDO_0004992) 0.84; per-cancer scores at or above 0.5: ovarian cancer 0.52, sarcoma 0.76, skin cancer 0.51, breast cancer 0.58, chondrosarcoma 0.75 (GraphQL API, CC0))
Glycosyltransferase forming with EXT2 the heterodimeric heparan sulfate polymerase which catalyses the elongation of the heparan sulfate glycan backbone. Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signalling. Location: Golgi apparatus membrane; Golgi apparatus, cis-Golgi network membrane; Endoplasmic reticulum membrane (UniProt). Locus 8q24.11 (HGNC).
Query for this target: (TITLE:"EXT1" OR ABSTRACT:"EXT1" OR TITLE:"exostosin glycosyltransferase 1" OR ABSTRACT:"exostosin glycosyltransferase 1" OR TITLE:"Exostosin-1" OR ABSTRACT:"Exostosin-1" OR TITLE:"ttv" OR ABSTRACT:"ttv") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EXT1, not a curated reading list.
Shares Chondrosarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.
Shares Chondrosarcoma, Sarcomas (soft tissue, bone, GIST), Open Targets Platform.