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EGF (Pro-epidermal growth factor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Cetuximab. Open Targets scores its association with cancer at 0.65 (direct and indirect evidence; datatypes literature 0.99, affected pathway 0.99, genetic association 0.23).
In plain words · EGF (Pro-epidermal growth factor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.
EGF (Pro-epidermal growth factor) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Head and neck squamous cell carcinoma.
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture.
No product in this corpus aims at EGF yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA group enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA EGF: RNA group enriched (kidney 103 nTPM, pancreas 84 nTPM, skeletal muscle 26 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Head and neck squamous cell carcinoma); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas EGF tissue; Open Targets ENSG00000138798 associations
First described 1977. Earliest sequence paper UniProt cites for the protein: Gregory et al, Int. J. Pept. Protein Res, 1977, "The primary structure of human urogastrone". Source.
Sources: HGNC HGNC:3229 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P01133 (protein name, function text, keywords and locations (REST API)); CIViC gene EGF (1 evidence items, 0 assertions, 1 variants; diseases: Head And Neck Squamous Cell Carcinoma (GraphQL API, CC0)); Open Targets ENSG00000138798 (association with cancer (MONDO_0004992) 0.65; (GraphQL API, CC0))
EGF stimulates the growth of various epidermal and epithelial tissues in vivo and in vitro and of some fibroblasts in cell culture. Magnesiotropic hormone that stimulates magnesium reabsorption in the renal distal convoluted tubule via engagement of EGFR and activation of the magnesium channel TRPM6. Can induce neurite outgrowth in motoneurons of the pond snail Lymnaea stagnalis in vitro. Location: Membrane (UniProt). Locus 4q25 (HGNC).
RNA: group enriched (kidney 103 nTPM, pancreas 84 nTPM, skeletal muscle 26 nTPM), detected in some normal tissues.
No normal tissue stained high.
RNA cancer enriched: Kidney Chromophobe 28 pTPM.
No cancer sample stained medium or high.
HPA EGF tissue · HPA EGF pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"EGF" OR ABSTRACT:"EGF" OR TITLE:"epidermal growth factor" OR ABSTRACT:"epidermal growth factor" OR TITLE:"Pro-epidermal growth factor" OR ABSTRACT:"Pro-epidermal growth factor") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EGF, not a curated reading list.
Shares Receptor tyrosine kinase activation, CIViC, Open Targets Platform.
Shares Receptor tyrosine kinase activation, Open Targets Platform.
Shares Receptor tyrosine kinase activation, CIViC, Open Targets Platform.
Shares Receptor tyrosine kinase activation, CIViC, Open Targets Platform.