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CCDC88C (coiled-coil and HOOK domain protein 88C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Required for activation of guanine nucleotide-binding proteins (G proteins) during non-canonical Wnt signalling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signalling. Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.70, animal model 0.74, genetic association 0.64).
In plain words · CCDC88C (coiled-coil and HOOK domain protein 88C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
CCDC88C (coiled-coil and HOOK domain protein 88C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Required for activation of guanine nucleotide-binding proteins (G proteins) during non-canonical Wnt signalling.
No product in this corpus aims at CCDC88C yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2000. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:19967 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9P219 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000015133 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0))
Required for activation of guanine nucleotide-binding proteins (G proteins) during non-canonical Wnt signalling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signalling. Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation. Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signalling. Promotes apical constriction of cells via ARHGEF18. Location: Cytoplasm; Cell junction (UniProt). Locus 14q32.11-q32.12 (HGNC).
Query for this target: (TITLE:"CCDC88C" OR ABSTRACT:"CCDC88C" OR TITLE:"coiled-coil and HOOK domain protein 88C" OR ABSTRACT:"coiled-coil and HOOK domain protein 88C" OR TITLE:"DAPLE" OR ABSTRACT:"DAPLE" OR TITLE:"HkRP2" OR ABSTRACT:"HkRP2" OR TITLE:"SCA40" OR ABSTRACT:"SCA40" OR TITLE:"KIAA1509" OR ABSTRACT:"KIAA1509") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CCDC88C, not a curated reading list.