{"entity":{"id":"ccdc88c","kind":"target","name":"CCDC88C","aka":["coiled-coil and HOOK domain protein 88C","DAPLE","HkRP2","SCA40","KIAA1509"],"tldr":"CCDC88C (coiled-coil and HOOK domain protein 88C) is a gene. In the public catalogues the evidence so far is association rather than a proven role.","summary":"Required for activation of guanine nucleotide-binding proteins (G proteins) during non-canonical Wnt signalling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signalling. Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation.\n\nOpen Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.70, animal model 0.74, genetic association 0.64).","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:19967","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19967"},{"label":"UniProt Q9P219","url":"https://www.uniprot.org/uniprotkb/Q9P219/entry"},{"label":"NCBI Gene 440193","url":"https://www.ncbi.nlm.nih.gov/gene/440193"},{"label":"Ensembl ENSG00000015133","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000015133"}],"tags":["cancer-genes-wave"],"related":["open-targets"],"cancers":[],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier \"association-only\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"CCDC88C","role":[],"evidenceTier":"association-only","sources":[{"label":"HGNC HGNC:19967","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19967","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9P219","url":"https://www.uniprot.org/uniprotkb/Q9P219/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"Open Targets ENSG00000015133","url":"https://platform.opentargets.org/target/ENSG00000015133/associations","note":"association with cancer (MONDO_0004992) 0.52;  (GraphQL API, CC0)"}],"specificitySources":[],"hgnc":"HGNC:19967","ensembl":"ENSG00000015133","uniprot":"Q9P219","entrez":"440193","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, \"Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/10819331/","biology":"Required for activation of guanine nucleotide-binding proteins (G proteins) during non-canonical Wnt signalling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signalling. Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation. Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signalling. Promotes apical constriction of cells via ARHGEF18. Location: Cytoplasm; Cell junction (UniProt). Locus 14q32.11-q32.12 (HGNC).","whereFound":[],"targetClass":"other","prevalence":[]},"route":"/targets/ccdc88c/","neighbours":{"collection":[{"id":"open-targets","kind":"collection","name":"Open Targets Platform","route":"/collections/open-targets/"}]}}