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CCDC88C (coiled-coil and HOOK domain protein 88C) is a gene. In the public catalogues the evidence so far is association rather than a proven role. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Required for activation of guanine nucleotide-binding proteins (G proteins) during non-canonical Wnt signalling. Binds to ligand-activated Wnt receptor FZD7, displacing DVL1 from the FZD7 receptor and leading to inhibition of canonical Wnt signalling. Acts as a non-receptor guanine nucleotide exchange factor by also binding to guanine nucleotide-binding protein G(i) alpha (Gi-alpha) subunits, leading to their activation. Binding to Gi-alpha subunits displaces the beta and gamma subunits from the heterotrimeric G protein complex, triggering non-canonical Wnt responses such as activation of RAC1 and PI3K-AKT signalling. Promotes apical constriction of cells via ARHGEF18. Location: Cytoplasm; Cell junction (UniProt). Locus 14q32.11-q32.12 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"CCDC88C" OR ABSTRACT:"CCDC88C" OR TITLE:"coiled-coil and HOOK domain protein 88C" OR ABSTRACT:"coiled-coil and HOOK domain protein 88C" OR TITLE:"DAPLE" OR ABSTRACT:"DAPLE" OR TITLE:"HkRP2" OR ABSTRACT:"HkRP2" OR TITLE:"SCA40" OR ABSTRACT:"SCA40" OR TITLE:"KIAA1509" OR ABSTRACT:"KIAA1509") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CCDC88C, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/ccdc88c.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ccdc88c.json. Licence CC BY-NC 4.0.