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Duke surgeon who led COMET, the trial testing whether women with low-risk DCIS can safely be monitored instead of having surgery straight away.
Shelley Hwang is a breast surgeon at Duke Cancer Institute whose research asks whether ductal carcinoma in situ is overtreated. She led the COMET trial, which randomised women with low-risk DCIS to guideline-concordant care or active monitoring with endocrine therapy, and was first author of its 2024 JAMA report showing that the rate of invasive cancer at two years was not worse with monitoring. She also leads laboratory work on the biology of DCIS progression.
| Title | Journal | Year |
|---|---|---|
| Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells Europe PMC author record matched by affiliation (Duke Cancer Institute); 857 citations on Europe PMC. | Cancer Cell | 2014 |
| Neoadjuvant Chemotherapy, Endocrine Therapy, and Targeted Therapy for Breast Cancer: ASCO Guideline Europe PMC author record matched by affiliation (Duke Cancer Institute); 840 citations on Europe PMC. | Journal of Clinical Oncology | 2021 |
| Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets Europe PMC author record matched by affiliation (Duke Cancer Institute); 818 citations on Europe PMC. | Cancer Cell | 2019 |
The last major guideline written before KEYNOTE-522 changed the standard; the 2022 rapid update reversed the immunotherapy line within a year.
One of the most cited papers Europe PMC returns for E. Shelley Hwang at Duke Cancer Institute, so it is a natural starting point for reading their work. The record was linked automatically from the author list and affiliation; read the abstract above and the paper itself before relying on any figure.
One of the most cited papers Europe PMC returns for E. Shelley Hwang at Duke Cancer Institute, so it is a natural starting point for reading their work. The record was linked automatically from the author list and affiliation; read the abstract above and the paper itself before relying on any figure.
Shares the tags breast, surgery, de-escalation.
Shares the tags breast, surgery, de-escalation.
Shares the tags surgery, de-escalation, trialist.
Shares Breast cancer (all types) and the tags breast, trialist.
Shares Ductal carcinoma in situ (DCIS), Breast cancer (all types) and the tags breast, trialist.
Shares the tags breast, trialist.
Shares the tags breast, trialist.
Shares Breast cancer (all types) and the tags breast, trialist.