{"entity":{"id":"shelley-hwang","kind":"person","name":"E. Shelley Hwang","aka":[],"tldr":"Duke surgeon who led COMET, the trial testing whether women with low-risk DCIS can safely be monitored instead of having surgery straight away.","summary":"Shelley Hwang is a breast surgeon at Duke Cancer Institute whose research asks whether ductal carcinoma in situ is overtreated. She led the COMET trial, which randomised women with low-risk DCIS to guideline-concordant care or active monitoring with endocrine therapy, and was first author of its 2024 JAMA report showing that the rate of invasive cancer at two years was not worse with monitoring. She also leads laboratory work on the biology of DCIS progression.","asOf":"2026-09-18","links":[],"tags":["breast","surgery","de-escalation","trialist"],"related":[],"cancers":["ductal-carcinoma-in-situ","breast-cancer"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["duke-cancer-institute"],"pathways":[],"terms":[],"trials":["comet-dcis"],"people":[],"bottlenecks":[],"keyPapers":["paper-shelley-hwang-cancer-cell-2014","paper-asco-neoadjuvant-therapy-breast-guideline-jco-2021","paper-shelley-hwang-cancer-cell-2019"],"journals":[],"dependsOn":[],"notes":[],"role":"Breast surgical oncologist, Duke Cancer Institute","institutionId":"duke-cancer-institute","specialisms":["Ductal carcinoma in situ","Active monitoring","Surgical de-escalation"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=Hwang%5BAuthor%5D"}],"papers":[{"title":"Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells","journal":"Cancer Cell","year":2014,"url":"https://doi.org/10.1016/j.ccell.2014.09.006","doi":"10.1016/j.ccell.2014.09.006","note":"Europe PMC author record matched by affiliation (Duke Cancer Institute); 857 citations on Europe PMC."},{"title":"Neoadjuvant Chemotherapy, Endocrine Therapy, and Targeted Therapy for Breast Cancer: ASCO Guideline","journal":"Journal of Clinical Oncology","year":2021,"url":"https://doi.org/10.1200/jco.20.03399","doi":"10.1200/jco.20.03399","note":"Europe PMC author record matched by affiliation (Duke Cancer Institute); 840 citations on Europe PMC."},{"title":"Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets","journal":"Cancer Cell","year":2019,"url":"https://doi.org/10.1016/j.ccell.2019.02.009","doi":"10.1016/j.ccell.2019.02.009","note":"Europe PMC author record matched by affiliation (Duke Cancer Institute); 818 citations on Europe PMC."}]},"route":"/people/shelley-hwang/","neighbours":{"cancer":[{"id":"breast-cancer","kind":"cancer","name":"Breast cancer (all types)","route":"/cancers/breast-cancer/"},{"id":"ductal-carcinoma-in-situ","kind":"cancer","name":"Ductal carcinoma in situ (DCIS)","route":"/cancers/ductal-carcinoma-in-situ/"}],"institution":[{"id":"duke-cancer-institute","kind":"institution","name":"Duke Cancer Institute","route":"/institutions/duke-cancer-institute/"}],"trial":[{"id":"comet-dcis","kind":"trial","name":"COMET (Comparison of Operative versus Monitoring and Endocrine Therapy)","route":"/trials/comet-dcis/"}],"paper":[{"id":"paper-shelley-hwang-cancer-cell-2019","kind":"paper","name":"Human Tumor-Associated Macrophage and Monocyte Transcriptional Landscapes Reveal Cancer-Specific Reprogramming, Biomarkers, and Therapeutic Targets","route":"/key-papers/paper-shelley-hwang-cancer-cell-2019/"},{"id":"paper-shelley-hwang-cancer-cell-2014","kind":"paper","name":"Macrophage IL-10 blocks CD8+ T cell-dependent responses to chemotherapy by suppressing IL-12 expression in intratumoral dendritic cells","route":"/key-papers/paper-shelley-hwang-cancer-cell-2014/"},{"id":"paper-asco-neoadjuvant-therapy-breast-guideline-jco-2021","kind":"paper","name":"Neoadjuvant Chemotherapy, Endocrine Therapy, and Targeted Therapy for Breast Cancer: ASCO Guideline","route":"/key-papers/paper-asco-neoadjuvant-therapy-breast-guideline-jco-2021/"}]}}