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Paper by E. Shelley Hwang indexed on Europe PMC as PubMed record 30930117, in Cancer Cell (2019), one of the most cited records naming an author with this name at Duke Cancer Institute.
The roles of tumor-associated macrophages (TAMs) and circulating monocytes in human cancer are poorly understood. Here, we show that monocyte subpopulation distribution and transcriptomes are significantly altered by the presence of endometrial and breast cancer. Furthermore, TAMs from endometrial and breast cancers are transcriptionally distinct from monocytes and their respective tissue-resident macrophages. We identified a breast TAM signature that is highly enriched in aggressive breast cancer subtypes and associated with shorter disease-specific survival. We also identified an auto-regulatory loop between TAMs and cancer cells driven by tumor necrosis factor alpha involving SIGLEC1 and CCL8, which is self-reinforcing through the production of CSF1. Together these data provide direct evidence that monocyte and macrophage transcriptional landscapes are perturbed by cancer, reflecting patient outcomes.
Indexed on Europe PMC as PubMed record 30930117 (DOI 10.1016/j.ccell.2019.02.009). Its author list gives "Hwang ES" with the affiliation "Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA", which names Duke Cancer Institute; that is how the record was matched to E. Shelley Hwang, and no figure has been checked by an editor.
One of the most cited papers Europe PMC returns for E. Shelley Hwang at Duke Cancer Institute, so it is a natural starting point for reading their work. The record was linked automatically from the author list and affiliation; read the abstract above and the paper itself before relying on any figure.