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Cancer neuroscience is the study of how tumours talk to nerves. Nerves grow into tumours and feed them signals; brain tumours even wire themselves into neural circuits. Cutting the conversation with common drugs such as beta-blockers is now being tested.
Perineural invasion predicts poor outcome in pancreatic, prostate, and head and neck cancer; sympathetic (β-adrenergic) and parasympathetic (muscarinic) signalling promotes growth and metastasis; tumours secrete NGF and axon-guidance factors to recruit nerves. Gliomas form functional synapses with neurons (AMPA receptors) and hijack activity-regulated neuroligin-3; neuronal activity drives glioma growth. Interventions: β-blockers (propranolol trials in melanoma, breast, angiosarcoma), botulinum toxin denervation (gastric cancer trial), NGF/TrkA blockade, AMPA antagonists (perampanel) in glioma, and gabapentinoids. A young field with strong preclinical evidence and early clinical signals.
A tumour that taps into the city's telephone lines: it receives growth orders from the nervous system, and brain tumours go further, plugging themselves into the switchboard so that ordinary brain chatter feeds them.
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One pathway page and one term page on OnCo cite this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing pages listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
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