Commissioned expert reviews on cancer biology. The place to start when learning a new area of tumour biology, from metabolism to metastasis.
Nature Reviews Cancer (Nat Rev Cancer) is a monthly review-only journal from Springer Nature, founded in 2001, publishing commissioned, peer-reviewed reviews by leading groups on cancer biology, plus shorter Perspectives and Comments. It does not publish primary research; its value lies in authoritative syntheses that define fields, which makes it the place to start when learning a new area of tumour biology, from metabolism to metastasis. Access is by subscription, with some content free. Within OnCo it is linked from the biographies of Mel Greaves, Erik Sahai, Drew Pardoll, Stephen Baylin, Charles Rudin and Alan D'Andrea, and a reader would use it for an expert overview before turning to primary papers.
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The organising framework for every small-cell lung cancer trial designed since. It is also why the slow progress in the disease is now attributed to treating four diseases as one rather than to the biology being intractable.
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One bottleneck page and 24 idea pages on OnCo cite this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing pages listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One bottleneck page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One of the most cited reviews Europe PMC returns for Androgen receptor in Prostate cancer, so it is a natural first reading for anyone weighing the idea it is linked from. The record was linked automatically by title and abstract; read the abstract above and the paper itself before relying on any figure.
One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
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This is the most cited map of the immunotherapy revolution and a good first read before the trials. Its predictions largely held: PD-1 pathway antibodies became the most widely used cancer drugs, PD-L1 testing entered practice, and LAG-3 blockade was approved in melanoma a decade later.
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One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One of the most cited reviews Europe PMC returns for JAK2 in Polycythaemia vera, so it is a natural first reading for anyone weighing the idea it is linked from. The record was linked automatically by title and abstract; read the abstract above and the paper itself before relying on any figure.
One term page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
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Two decades on, the disease is still described as understudied in the 2025 immunogenomics literature; the reasons (rarity in the countries that fund research, incidental diagnosis, pooling with bile duct cancer in trials) have not changed.
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This is the paper that made EMT a cancer concept, cited by almost every metastasis study since. It set the research agenda that later produced the EMT stem cell link and current work on partial EMT states.
Mapped the Fanconi anaemia/BRCA DNA repair pathway and how tumours become resistant to PARP inhibitors.
Cambridge haematologist and EHA President Elect whose laboratory studies how epigenetic regulators drive leukaemia and how they can be targeted.
Defined the molecular subtypes of small-cell lung cancer and led early trials of DLL3-targeted therapy.
Paediatric haematologist-oncologist and National Academy of Medicine member who is Interim Director of the IU Simon Comprehensive Cancer Center in Indianapolis.
Professor of urology and of cellular and molecular medicine who directs the University of Arizona Cancer Center, the NCI-designated cancer centre in Tucson.
Immunologist who helped define the PD-1 pathway's role in cancer and built one of the largest immunotherapy institutes.
Cell biologist studying how the tumour's surroundings help cancer cells invade and resist drugs.
Iain Foulkes directs the research portfolio of Cancer Research UK.
Cambridge medical oncologist and Interim Deputy Director of the CRUK Cambridge Institute, a leader in ovarian cancer genomics and ctDNA monitoring.
Working part-time at her dining-room table in 1972, she showed the Philadelphia chromosome in CML is a swap between chromosomes 9 and 22. Cancer had a genetic cause, and imatinib later hit the fused gene.
Immunologist who directs the NCI-designated JAX Cancer Center at The Jackson Laboratory and holds its Edison T. Liu Endowed Chair in Cancer Research.
Showed that childhood leukaemia begins before birth and framed cancer as an evolutionary process.
Michael Baumann is a radiation oncologist who leads Germany's national cancer research centre.
Cancer biologist who directs the NCI-designated Salk Cancer Center in La Jolla and holds the William R. Brody Chair at the Salk Institute.
Physician who leads VCU Massey Comprehensive Cancer Center in Richmond, Virginia, the NCI-designated comprehensive cancer centre of Virginia Commonwealth University.
Drug development oncologist who directs the OHSU Knight Cancer Institute.
Founder of cancer epigenetics, showing that abnormal DNA methylation silences tumour-suppressor genes and can be reversed by drugs.
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One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.
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One pathway page on OnCo cites this paper by its DOI; this record gives the citation a page of its own so a reader can follow it without leaving OnCo. Read the abstract above alongside the citing page listed under Related; the record was created automatically from the Europe PMC entry and its figures have not been checked by hand.