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The review that brought the developmental idea of epithelial-mesenchymal transition into cancer biology, proposing it as the mechanism by which carcinoma cells detach, invade and travel to distant sites.
Thiery reviewed the evidence that carcinomas use an epithelial-mesenchymal transition to progress: loss of E-cadherin-based junctions, cytoskeletal remodelling and gain of migratory behaviour, driven by signals including TGF-beta, receptor tyrosine kinases, Wnt and the transcription factors Snail and Twist. He drew the parallel with gastrulation and neural crest migration in embryos and argued that EMT, and its reversal at secondary sites, could account for how metastases arise and why they often look epithelial again.
This is the paper that made EMT a cancer concept, cited by almost every metastasis study since. It set the research agenda that later produced the EMT stem cell link and current work on partial EMT states.
This is the reference for the mechanics behind invasion and metastasis and for why partial EMT states, rather than a full switch, are now thought to matter most in cancer. It also explains the appeal and the difficulty of drugging EMT, since its drivers are transcription factors.
EMT is the most cited explanation for how carcinomas invade and spread and for part of their drug resistance. This primer is the entry point for the field, and its framework informs current work on partial EMT states, circulating tumour cells and therapies aimed at the transition.
Shares Hallmark: activating invasion and metastasis, Metastasis.
Shares Kalluri and Weinberg 2009: the basics of epithelial-mesenchymal transition, Metastasis, Epithelial-mesenchymal transition & drug efflux.
Shares Hallmark: activating invasion and metastasis, Metastasis, Epithelial-mesenchymal transition & drug efflux.
Shares Hallmark: activating invasion and metastasis, Metastasis.
Shares Hallmark: activating invasion and metastasis, Metastasis, The metastatic cascade.
Shares Metastasis, The metastatic cascade.
Shares Lamouille 2014: molecular mechanisms of epithelial-mesenchymal transition, Kalluri and Weinberg 2009: the basics of epithelial-mesenchymal transition, Hallmark: activating invasion and metastasis, The metastatic cascade.
Shares Metastasis, The metastatic cascade.