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Leiden University Medical Center
Leiden's university hospital, a cradle of therapeutic cancer vaccines and tumour immunology and the base for the Dutch TME rectal cancer trial.
Also called: LUMCLeiden Oncology Center
Overview
The LUMC's tumour immunology tradition runs from Cornelis Melief's synthetic long peptide HPV16 vaccine, developed with ISA Pharmaceuticals, to the immunology groups of Sjoerd van der Burg and Ferry Ossendorp, and Ton Schumacher and John Haanen of the Netherlands Cancer Institute hold Leiden professorships. Cornelis van de Velde's Dutch TME trial established total mesorectal excision with short-course radiotherapy as the standard for rectal cancer, and Judith Bovée's pathology group is a world reference for bone and soft tissue tumours. Leiden co-owns the Holland Proton Therapy Centre and runs a large haematology and transplant programme. The Leiden Oncology Center coordinates care with regional hospitals.
Location
Leiden, NL
Type
university · Leiden University
Website
Newsweek 2026 oncology rank
Not in top 300 listing used
OnCo score
#209 · 28 points (0 Newsweek + 0 NCI + 28 from 14 linked objects) · ranking
Research output
From OpenAlex, oncology works in the last five years (2022 to 2026, current year in progress); counted on 2026-09-16.
Matched to Leiden University Medical Center, including child institutions. 1,245 works · 16,125 citations · 82% open access · 11% clinical trials · 3% reviews.
Oncology works per year
2722022
2902023
2532024
2742025
1562026
Most works
- Marc G. Besselink135 works
- Bas Groot Koerkamp123 works
- Bert A. Bonsing100 works
- Ignace H. J. T. de Hingh81 works
- J. Sven D. Mieog78 works
- Olivier R. Busch75 works
- John B.A.G. Haanen70 works
- Ellen Kapiteijn69 works
- Hjalmar C. van Santvoort66 works
- Martijn W.J. Stommel65 works
Most cited
- Therapeutic cancer vaccines
- Tumour immunology
- Rectal cancer surgery and radiotherapy
- Bone and soft tissue tumour pathology
- HollandPTC
Carien L. Creutzberg
Professor of Radiation Oncology, Leiden University Medical Center
Endometrial cancerRadiotherapyMolecular classification
Led the PORTEC trials that defined who needs radiotherapy for endometrial cancer and brought molecular classification into treatment decisions.
Cornelis J. H. van de Velde
Emeritus Professor of Surgical Oncology, Leiden University Medical Center
Colorectal surgeryTotal mesorectal excisionGastric cancer surgery
Surgeon who led the Dutch TME trial, proving standardised rectal surgery with radiotherapy cuts local recurrence.
Martin Jan Schalij
Chair of the Executive Board
CardiologyHospital leadership
Cardiologist who chairs the Executive Board of Leiden University Medical Center.
Ton Schumacher
Senior Group Leader, Netherlands Cancer Institute; Professor, Leiden University
T-cell immunologyNeoantigensTCR discovery
Immunologist who showed T cells recognise cancer neoantigens, the basis for personalised vaccines and TCR therapies.
John Haanen
Medical Oncologist, Netherlands Cancer Institute; Professor, Leiden University Medical Center
MelanomaTIL therapyImmunotherapy
John Haanen led the first randomised phase 3 trial of TIL therapy, which beat ipilimumab in melanoma.
Similar pages
- Key paperRohaas 2022: the first randomised trial of TIL therapy, against ipilimumab, in advanced melanoma
Shares Ton Schumacher, John Haanen, Netherlands Cancer Institute (NKI-AvL), Melanoma.
- IdeaSelect patients for cell therapy by whether their tumour holds reactive T cells
Shares Ton Schumacher, John Haanen, Melanoma.
- PersonWinette T. A. van der Graaf
Shares Erasmus MC Cancer Institute, Netherlands Cancer Institute (NKI-AvL), Sarcomas (soft tissue, bone, GIST).
- Key paperNICHE-2: a month of nivolumab and ipilimumab before surgery clears mismatch-repair-deficient colon cancer in most patients
Shares Ton Schumacher, John Haanen, Netherlands Cancer Institute (NKI-AvL), Colorectal cancer.
- Key paperPreoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer (Dutch TME trial)
Shares Cornelis J. H. van de Velde, Erasmus MC Cancer Institute, Colorectal cancer.
- TermCancer vaccines and oncolytic viruses
Shares Off-the-shelf cancer vaccines, HPV & HBV vaccination, Cervical cancer, Melanoma.
- IdeaCheck whether a tumour can still show itself to the immune system
Shares Ton Schumacher, Neoantigen, Immune checkpoint inhibitors.
- Key paperNADINA: two doses of ipilimumab plus nivolumab before surgery beat a year of nivolumab after surgery in stage III melanoma
Shares John Haanen, Netherlands Cancer Institute (NKI-AvL), Melanoma, Immune checkpoint inhibitors.