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Surgeon who led the Dutch TME trial, proving standardised rectal surgery with radiotherapy cuts local recurrence.
Cornelis van de Velde led the Dutch TME trial, which showed that total mesorectal excision taught through a national quality programme combined with short-course preoperative radiotherapy reduces local recurrence in rectal cancer, and the Dutch D1-D2 gastric cancer trial that clarified the role of extended lymphadenectomy. He founded the EURECCA registry programme and has been president of ESSO and ECCO.
The first total neoadjuvant therapy trial to change practice in high-risk rectal cancer, and the schedule that makes organ preservation possible by giving the tumour months rather than weeks to respond.
The modern basis for offering short-course radiotherapy selectively: it buys local control, not survival, so the decision turns on the predicted recurrence risk from MRI against the long-term bowel and sexual morbidity of pelvic irradiation.
Shares Colorectal cancer roadmap: from the adenoma-carcinoma sequence and the first screening trials to total mesorectal excision, oxaliplatin, RAS testing, immunotherapy for mismatch repair-deficient disease, ctDNA-guided treatment and organ preservation, Colorectal cancer and the tags surgery, colorectal.
Shares Colorectal cancer and the tags surgery, colorectal.
Shares Colorectal cancer roadmap: from the adenoma-carcinoma sequence and the first screening trials to total mesorectal excision, oxaliplatin, RAS testing, immunotherapy for mismatch repair-deficient disease, ctDNA-guided treatment and organ preservation, Colorectal cancer and the tag colorectal.
Shares European Society of Surgical Oncology, Colorectal cancer.
Shares Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer (Dutch TME trial), Colorectal cancer roadmap: from the adenoma-carcinoma sequence and the first screening trials to total mesorectal excision, oxaliplatin, RAS testing, immunotherapy for mismatch repair-deficient disease, ctDNA-guided treatment and organ preservation, Colorectal cancer.
Shares Colorectal cancer and the tag colorectal.
Shares Colorectal cancer and the tag colorectal.
Shares Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer (Dutch TME trial), Colorectal cancer roadmap: from the adenoma-carcinoma sequence and the first screening trials to total mesorectal excision, oxaliplatin, RAS testing, immunotherapy for mismatch repair-deficient disease, ctDNA-guided treatment and organ preservation, Colorectal cancer.