{"entity":{"id":"cornelis-van-de-velde","kind":"person","name":"Cornelis J. H. van de Velde","aka":[],"tldr":"Surgeon who led the Dutch TME trial, proving standardised rectal surgery with radiotherapy cuts local recurrence.","summary":"Cornelis van de Velde led the Dutch TME trial, which showed that total mesorectal excision taught through a national quality programme combined with short-course preoperative radiotherapy reduces local recurrence in rectal cancer, and the Dutch D1-D2 gastric cancer trial that clarified the role of extended lymphadenectomy. He founded the EURECCA registry programme and has been president of ESSO and ECCO.","asOf":"2026-09-10","links":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=van%20de%20Velde%20CJ%5BAuthor%5D%20rectal%20TME"}],"tags":["surgery","colorectal","quality"],"related":[],"cancers":["colorectal","gastric"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":["lumc-leiden","esso"],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":[],"role":"Emeritus Professor of Surgical Oncology, Leiden University Medical Center","institutionId":"lumc-leiden","specialisms":["Colorectal surgery","Total mesorectal excision","Gastric cancer surgery","Surgical quality"],"profiles":[{"label":"PubMed","url":"https://pubmed.ncbi.nlm.nih.gov/?term=van%20de%20Velde%20CJ%5BAuthor%5D%20rectal%20TME"}],"papers":[{"title":"Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer (Dutch TME trial)","journal":"NEJM","year":2001,"doi":"10.1056/NEJM200108303450901"},{"title":"Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial","journal":"Lancet Oncology","year":2010,"doi":"10.1016/S1470-2045(10)70070-X"}]},"route":"/people/cornelis-van-de-velde/","neighbours":{"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"},{"id":"gastric","kind":"cancer","name":"Gastric & gastro-oesophageal junction cancer","route":"/cancers/gastric/"}],"institution":[{"id":"esso","kind":"institution","name":"European Society of Surgical Oncology","route":"/institutions/esso/"},{"id":"lumc-leiden","kind":"institution","name":"Leiden University Medical Center","route":"/institutions/lumc-leiden/"}],"paper":[{"id":"paper-kapiteijn-dutch-tme-preoperative-radiotherapy-nejm-2001","kind":"paper","name":"Preoperative radiotherapy combined with total mesorectal excision for resectable rectal cancer (Dutch TME trial)","route":"/key-papers/paper-kapiteijn-dutch-tme-preoperative-radiotherapy-nejm-2001/"},{"id":"paper-bahadoer-rapido-short-course-radiotherapy-lancet-oncol-2021","kind":"paper","name":"Short-course radiotherapy followed by chemotherapy before total mesorectal excision versus preoperative chemoradiotherapy in locally advanced rectal cancer (RAPIDO)","route":"/key-papers/paper-bahadoer-rapido-short-course-radiotherapy-lancet-oncol-2021/"}],"roadmap":[{"id":"colorectal-roadmap","kind":"roadmap","name":"Colorectal cancer roadmap: from the adenoma-carcinoma sequence and the first screening trials to total mesorectal excision, oxaliplatin, RAS testing, immunotherapy for mismatch repair-deficient disease, ctDNA-guided treatment and organ preservation","route":"/roadmaps/colorectal-roadmap/"}]}}