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institutionsInstitution
Frederick National Laboratory for Cancer Research
The only US national laboratory dedicated to biomedical research, run for the NCI; home of the RAS Initiative and NCI's experimental drug manufacturing.
Also called: FNLCRNCI-FrederickNCI at Frederick
Overview
Frederick National Laboratory is a federally funded research and development centre sponsored by the NCI and operated under contract by Leidos Biomedical Research on the Fort Detrick campus. Its RAS Initiative, launched in 2013 with Frank McCormick as scientific advisor, built the structural, biochemical and screening infrastructure that helped make KRAS druggable. The laboratory manufactures experimental biologics, cell therapies and vaccines to cGMP standards for NCI and NIH trials (its Vaccine Clinical Materials Program produced the first clinical lots for Moderna's COVID-19 vaccine), hosts the National Cryo-EM Facility, and provides genomics, proteomics, nanotechnology characterisation and AI-driven drug design through the ATOM consortium. It also supports NCI's AIDS and cancer virus, natural products and biorepository programmes.
Location
Frederick, MD, US
Type
government
Website
Newsweek 2026 oncology rank
Not in top 300 listing used
OnCo score
#356 · 18 points (0 Newsweek + 0 NCI + 18 from 9 linked objects) · ranking
Research output
From OpenAlex, oncology works in the last five years (2022 to 2026, current year in progress); counted on 2026-10-01.
Matched to Frederick National Laboratory for Cancer Research, including child institutions. 320 works · 3,921 citations · 85% open access · 8% clinical trials · 1% reviews.
Oncology works per year
522022
772023
682024
622025
612026
Most works
- Denise Whitby37 works
- Robert Yarchoan24 works
- Ramya Ramaswami24 works
- Kathryn Anne Lurain22 works
- Nazzarena Labò22 works
- Wendell Miley20 works
- James H. Doroshow18 works
- Vickie Ann Marshall18 works
- Þorkell Andrésson17 works
- Laurie T. Krug16 works
Most cited
- RAS Initiative
- Biopharmaceutical development and cGMP manufacturing
- National Cryo-EM Facility
- ATOM AI drug discovery
Jay Schnitzer
Director, Frederick National Laboratory
Biomedical research managementSurgeryTechnology development
Physician-scientist who directs the Frederick National Laboratory for Cancer Research, the US national laboratory dedicated to cancer and AIDS research.
Frank McCormick
Professor, UCSF Helen Diller Family Comprehensive Cancer Center; former Scientific Lead, NCI RAS Initiative
RAS biologySignal transductionDrug discovery
RAS biologist who founded Onyx Pharmaceuticals and led the NCI's national effort to drug RAS.
Similar pages
- Key paperMost human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
Shares Frank McCormick, The undruggable drivers, KRAS.
- IdeaAn open map of which cancer proteins any drug can stick to
Shares Proteomics & phosphoproteomics, AI-driven drug & target discovery, The undruggable drivers.
- CompanyTreeline Biosciences
Shares AI-driven drug & target discovery, KRAS & RAS inhibitors, KRAS.
- CompanyQuanta Therapeutics
Shares KRAS & RAS inhibitors, The undruggable drivers, KRAS.
- PersonSteven A. Rosenberg
Shares NCI Center for Cancer Research (intramural programme), National Cancer Institute (NIH), KRAS.
- InstitutionCentro Nacional de Investigaciones Oncológicas (CNIO)
Shares AI-driven drug & target discovery, KRAS & RAS inhibitors, The undruggable drivers, KRAS.
- TrialKRYSTAL-12
Shares KRAS & RAS inhibitors, The undruggable drivers, KRAS.
- PersonBrigitte C. Widemann
Shares NCI Center for Cancer Research (intramural programme), National Cancer Institute (NIH).