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Vinflunine (Javlor) is a chemotherapy infusion used in Europe as a second treatment for advanced bladder cancer after platinum chemotherapy has stopped working.
Vinflunine was authorised by the European Commission in September 2009 as monotherapy for advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of a prior platinum-containing regimen, on a phase 3 trial of 370 patients against best supportive care in which median overall survival improved modestly, a statistically significant difference in the eligible population, making it the first drug with level 1 evidence in second-line urothelial cancer. It is not approved in the US, where the FDA declined the application. Pembrolizumab, enfortumab vedotin and erdafitinib have since displaced it in most guidelines, but it remains an option where immunotherapy is unsuitable. Neutropenia, constipation (prophylactic laxatives are recommended), fatigue and QT prolongation are the main adverse effects. Marketed by Pierre Fabre.
Ball-and-stick model from PubChem 2D record (no 3D conformer available). PubChem record
Third-generation vinca alkaloid that binds tubulin with lower affinity than vinorelbine, suppressing microtubule dynamics and causing mitotic arrest; less neurotoxic than earlier vincas.
1.Vinflunine slips into a pocket on its target.
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| Region | Year | Indication |
|---|---|---|
| EU | 2009 | Advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of a platinum-containing regimen |
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Query for this drug: (TITLE:"Vinflunine" OR ABSTRACT:"Vinflunine" OR TITLE:"Javlor" OR ABSTRACT:"Javlor") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Vinflunine, not a curated reading list.
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