Pierre Fabre is a French pharmaceutical and dermo-cosmetics group whose oncology franchise includes vinorelbine (Navelbine), vinflunine (Javlor) and the BRAF/MEK pair encorafenib and binimetinib in Europe.
Pierre Fabre, based in Castres, is a French pharmaceutical and dermo-cosmetics group whose oncology franchise includes vinorelbine, sold as Navelbine, vinflunine, sold as Javlor, and the BRAF and MEK pair encorafenib and binimetinib in Europe. It originated the vinca alkaloids vinorelbine and vinflunine, markets Braftovi and Mektovi in Europe under licence from Array and Pfizer, and sells busulfan as Busilvex and other haematology products. OnCo links it to the vinflunine drug record. Whether a mid-sized European company can keep a targeted therapy franchise built on in-licensed products as their originators change hands is the open question. Vinflunine has its own page.
Vinorelbine is a vinca chemotherapy for lung and breast cancer, available orally, and is now part of maintenance therapy that improved survival in childhood rhabdomyosarcoma.
Vinflunine (Javlor) is a chemotherapy infusion used in Europe as a second treatment for advanced bladder cancer after platinum chemotherapy has stopped working.
Encorafenib is a BRAF inhibitor that, with cetuximab and chemotherapy, became first-line standard for BRAF-mutant colorectal cancer in 2026.
Binimetinib is the MEK inhibitor partnered with encorafenib; blocking the next step in the same relay stops the tumour rerouting around the BRAF block.
Busulfan is one of the oldest cancer drugs. As a tablet it controlled chronic myeloid leukaemia before imatinib; as an infusion it is used to clear the bone marrow before a stem cell transplant.
Hemangeol is a liquid form of the blood-pressure drug propranolol approved to shrink infantile haemangiomas, the common benign blood-vessel tumours of babies, replacing steroids and surgery for most children who need treatment.
Tabelecleucel is a bank of donor T cells trained against Epstein-Barr virus, approved in Europe in 2022 as the first off-the-shelf T-cell therapy, for EBV-driven lymphoma after transplant when rituximab has failed.
Shares A Phase 3 Study of Tabelecleucel for Participants With Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease After Failu, Tabelecleucel, A Study to Evaluate Tabelecleucel in Participants With Epstein Barr Virus (EBV) Associated Diseases.
Shares Encorafenib + Cetuximab Beyond Progression in Combination With FOLFIRI in Patients With BRAF V600E Mutated Metastatic Colorectal Cancer Progressing on Encorafen, Study to Evaluate the Efficacy and Safety of Cetuximab in Combination with Encorafenib Plus Binimetinib As Induction Treatment in BRAF V600E Mutated MSS Initial, Encorafenib Plus Cetuximab in a Neoadjuvant Setting in Patients With BRAF Mutation Localised Colon or Upper Rectum Cancer, Binimetinib.
Shares Binimetinib, MEK1/2, Encorafenib, BRAF.
Shares Binimetinib, Encorafenib, BRAF, Pfizer (incl. Seagen).
Shares Phase II Study Investigating the Combination of Encorafenib and Binimetinib in BRAF V600E Mutated Chinese Patients With Metastatic Non-Small Cell Lung, Binimetinib, Encorafenib, BRAF.
Shares Binimetinib, Encorafenib, BRAF, Pfizer (incl. Seagen).
Shares Binimetinib, MEK1/2, Encorafenib, BRAF.
Shares Binimetinib, Encorafenib, Pfizer (incl. Seagen).