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Vindesine is a vinca alkaloid, a semi-synthetic relative of vinblastine, used in Europe and elsewhere for acute lymphoblastic leukaemia and some solid tumours; it was never marketed in the United States.
Vindesine is made from vinblastine and shares the class mechanism of the vinca alkaloids, binding tubulin so microtubules cannot form. It has been used in acute lymphoblastic leukaemia in children and adults, in non-small cell lung cancer combinations in the 1980s and 1990s, and in melanoma and breast cancer, mostly in European protocols. Peripheral neuropathy is its dose-limiting toxicity. It remains a licensed medicine in several European countries but has largely given way to vincristine and vinorelbine.
Ball-and-stick model from PubChem 2D record (no 3D conformer available). PubChem record
Binds tubulin and blocks microtubule assembly, arresting dividing cells in metaphase. Connects to Tubulin (microtubules).
1.Vindesine slips into a pocket on Tubulin (microtubules).
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Query for this drug: (TITLE:"Vindesine" OR ABSTRACT:"Vindesine" OR TITLE:"Eldisine" OR ABSTRACT:"Eldisine" OR TITLE:"Desacetylvinblastine amide" OR ABSTRACT:"Desacetylvinblastine amide" OR TITLE:"DVA" OR ABSTRACT:"DVA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Vindesine, not a curated reading list.
Shares Tubulin (microtubules), Cytotoxic chemotherapy and the tag chembl-universe.
Shares Acute lymphoblastic leukaemia, Cytotoxic chemotherapy and the tag chembl-universe.
Shares Eli Lilly (incl. Loxo) and the tag chembl-universe.
Shares Acute lymphoblastic leukaemia, Cytotoxic chemotherapy and the tag chembl-universe.
Shares Cytotoxic chemotherapy, Non-small-cell lung cancer and the tag chembl-universe.
Shares Eli Lilly (incl. Loxo) and the tag chembl-universe.
Shares Cytotoxic chemotherapy and the tag chembl-universe.
Shares Cytotoxic chemotherapy, Non-small-cell lung cancer and the tag chembl-universe.