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Amsacrine is an intravenous leukaemia drug, approved in Europe, Canada and Australia in the 1980s, used mainly for acute myeloid leukaemia that has relapsed or resisted anthracycline-based treatment.
Amsacrine was synthesised in New Zealand by Bruce Cain's group and was the first synthetic DNA-intercalating agent to reach the clinic. It has been approved since the 1980s in several European countries, Canada and Australia for induction and consolidation of relapsed or refractory acute myeloid leukaemia, often with cytarabine and etoposide, and appears in some acute lymphoblastic leukaemia salvage protocols. It was never approved in the United States, where it remained investigational. Cardiac arrhythmias in patients with low potassium and the usual marrow suppression are the main hazards.
An intercalating acridine that traps topoisomerase II on DNA, producing double-strand breaks in dividing cells. Connects to Topoisomerase II alpha (TOP2A).
1.Amsacrine slips into a pocket on Topoisomerase II alpha (TOP2A).
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Query for this drug: (TITLE:"Amsacrine" OR ABSTRACT:"Amsacrine" OR TITLE:"Amsidine" OR ABSTRACT:"Amsidine" OR TITLE:"Amsidyl" OR ABSTRACT:"Amsidyl" OR TITLE:"m-AMSA" OR ABSTRACT:"m-AMSA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Amsacrine, not a curated reading list.
Shares Topoisomerase II alpha (TOP2A), Etoposide, Acute lymphoblastic leukaemia, Cytotoxic chemotherapy and the tag chembl-universe.
Shares Topoisomerase II alpha (TOP2A), Cytotoxic chemotherapy and the tag chembl-universe.
Shares Acute lymphoblastic leukaemia, Cytotoxic chemotherapy and the tag chembl-universe.
Shares Cytotoxic chemotherapy and the tag chembl-universe.
Shares Cytotoxic chemotherapy and the tag chembl-universe.
Shares Cytotoxic chemotherapy and the tag chembl-universe.
Shares Cytotoxic chemotherapy and the tag chembl-universe.
Shares Cytotoxic chemotherapy and the tag chembl-universe.