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Teniposide is a close relative of etoposide approved in the United States in 1992 for children whose acute lymphoblastic leukaemia has come back after induction, and used in Europe for childhood brain tumours and neuroblastoma.
Teniposide was synthesised alongside etoposide at Sandoz in the 1960s and is roughly ten times more potent in vitro. The FDA approved it in 1992, in combination with other agents, for induction in children with refractory acute lymphoblastic leukaemia, based on Children's Cancer Group and St Jude experience. It has been used in Europe in neuroblastoma, small cell lung cancer and lymphomas. Hypersensitivity reactions to its polysorbate vehicle and the class risk of secondary acute myeloid leukaemia limited it, and etoposide became the standard podophyllotoxin. Bristol-Myers Squibb discontinued Vumon in most markets.
Stabilises the complex between topoisomerase II and DNA so the double-strand breaks the enzyme makes are not resealed. Connects to Topoisomerase II alpha (TOP2A).
1.Teniposide slips into a pocket on Topoisomerase II alpha (TOP2A).
| Region | Year | Indication |
|---|---|---|
| US | 1992 | Refractory childhood acute lymphoblastic leukaemia, in combination induction |
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Query for this drug: (TITLE:"Teniposide" OR ABSTRACT:"Teniposide" OR TITLE:"Vumon" OR ABSTRACT:"Vumon" OR TITLE:"VM-26" OR ABSTRACT:"VM-26") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Teniposide, not a curated reading list.
Shares Topoisomerase II alpha (TOP2A), Etoposide, Acute lymphoblastic leukaemia, Cytotoxic chemotherapy and the tag chembl-universe.
Shares Topoisomerase II alpha (TOP2A), Cytotoxic chemotherapy and the tag chembl-universe.
Shares Acute lymphoblastic leukaemia, Cytotoxic chemotherapy and the tag chembl-universe.
Shares Cytotoxic chemotherapy and the tag chembl-universe.
Shares Cytotoxic chemotherapy and the tag chembl-universe.
Shares Cytotoxic chemotherapy and the tag chembl-universe.
Shares Cytotoxic chemotherapy and the tag chembl-universe.
Shares Cytotoxic chemotherapy and the tag chembl-universe.