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Alitretinoin gel is a vitamin A derivative applied directly to Kaposi sarcoma skin lesions in people with AIDS, approved in the United States in 1999 as the first topical treatment for the disease.
Alitretinoin (9-cis-retinoic acid) activates every known retinoid receptor. As Panretin gel it was approved by the FDA in February 1999 for cutaneous lesions of AIDS-related Kaposi sarcoma in patients who do not need systemic therapy, on the basis of two randomised trials in which about a third of lesions responded. Skin irritation at the application site is the main side effect. The oral form is approved in Europe for severe chronic hand eczema, not for cancer.
A natural retinoid that binds both retinoic acid receptors and retinoid X receptors, switching on genes that slow proliferation and induce differentiation in Kaposi sarcoma cells.
1.Alitretinoin acts on its target, the hormone receptor or the enzyme that makes the hormone.
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| Region | Year | Indication |
|---|---|---|
| US | 1999 | Cutaneous lesions of AIDS-related Kaposi sarcoma (topical gel) |
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Query for this drug: (TITLE:"Alitretinoin" OR ABSTRACT:"Alitretinoin" OR TITLE:"Panretin" OR ABSTRACT:"Panretin" OR TITLE:"9-cis-retinoic acid" OR ABSTRACT:"9-cis-retinoic acid") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Alitretinoin, not a curated reading list.
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