Loading
Sterile talc is puffed or instilled into the chest cavity after fluid is drained to make the lung stick to the chest wall, stopping cancer-related fluid (malignant pleural effusion) from building up again.
Sclerosol intrapleural aerosol was approved by the FDA in December 1997 and sterile talc powder in 2003 to decrease the recurrence of malignant pleural effusion in symptomatic patients after drainage; talc has been the most effective pleurodesis agent in comparative trials and meta-analyses for decades. Poudrage at thoracoscopy and bedside slurry through a chest drain give similar success (TAPPS trial), and indwelling pleural catheters, with or without talc instilled through them (IPC-PLUS), are the main alternative for patients with trapped lung or short prognosis. Graded, large-particle talc is used to avoid the acute respiratory distress syndrome reported with small-particle preparations. Fever and chest pain after the procedure are expected.
Ball-and-stick model from PubChem 2D record (no 3D conformer available). PubChem record
Talc is a layered magnesium silicate mineral, not a discrete molecule; PubChem's formula-unit record is shown.
Sterile asbestos-free magnesium silicate that provokes an inflammatory pleuritis and fibrosis, sealing the visceral and parietal pleura together so that fluid can no longer accumulate.
1.Talc (intrapleural) slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 1997 | Prevention of recurrence of malignant pleural effusion after drainage (Sclerosol aerosol; sterile powder 2003) |
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"Talc" OR ABSTRACT:"Talc" OR TITLE:"intrapleural" OR ABSTRACT:"intrapleural" OR TITLE:"Sclerosol" OR ABSTRACT:"Sclerosol" OR TITLE:"Sterile Talc Powder" OR ABSTRACT:"Sterile Talc Powder" OR TITLE:"Steritalc" OR ABSTRACT:"Steritalc" OR TITLE:"Talc slurry" OR ABSTRACT:"Talc slurry") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Talc (intrapleural), not a curated reading list.
Shares Early integrated palliative care, HR-positive / HER2-negative breast cancer, Non-small-cell lung cancer and the tag supportive.
Shares Early integrated palliative care and the tag supportive.
Shares Early integrated palliative care and the tag supportive.
Shares Ovarian cancer and the tag supportive.
Shares HR-positive / HER2-negative breast cancer, Non-small-cell lung cancer and the tag supportive.
Shares HR-positive / HER2-negative breast cancer, Non-small-cell lung cancer and the tag supportive.
Shares Early integrated palliative care, Non-small-cell lung cancer and the tag supportive.
Shares HR-positive / HER2-negative breast cancer and the tag supportive.