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Trials
Video-Assisted Surgery or Talc Pleurodesis in Treating Patients With Malignant Mesothelioma

trialsTrialCompleted

Video-Assisted Surgery or Talc Pleurodesis in Treating Patients With Malignant Mesothelioma

A phase 3 trial of Talc in Mesothelioma and Metastatic cancer, run by Papworth Hospital NHS Foundation Trust, completed.

Also called: MesoVATS

Overview Connected3

Overview

Video-Assisted Surgery or Talc Pleurodesis in Treating Patients With Malignant Mesothelioma is a phase 3 interventional study registered as NCT00821860 by Papworth Hospital NHS Foundation Trust, with 196 participants recorded, started 2003-09 and reaching its primary completion in 2013-02. Interventions recorded: talc, therapeutic thoracoscopy, therapeutic videothoracoscopy. Conditions recorded: Malignant Mesothelioma, Metastatic Cancer.

Linked to the drug Talc because the registry names it among its interventions and Mesothelioma and Metastatic cancer among its conditions. Registry record only: no result has been read by an editor.

Setting

Prospective Randomised Controlled Trial of Video-Assisted Thoracoscopic (VAT) Cytoreductive Pleurectomy Compared to Talc Pleurodesis in Patients With Suspected or Proven Malignant Mesothelioma

Phase

Phase 3

Sponsor

Papworth Hospital NHS Foundation Trust

Registry

Started

2003-09

Enrolled

196 enrolled

Connected

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cancers

Mesothelioma Metastatic cancer (cancer that has spread)

drugs

ApprovedSclerosing agent (intrapleural powder or aerosol)

Talc (intrapleural) · Sclerosol / Sterile Talc Powder / Steritalc

Evidence strength46/100 · Emerging

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 3+30
196 enrolled+11
No structured primary endpoint0
Result: completed0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-22 · Jude Gomila · Wave 5 drugs · diff · file

Sources & links

ClinicalTrials.gov NCT00821860

Data

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Cancers

Mesothelioma
Metastatic cancer (cancer that has spread)

Products

Talc (intrapleural)

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WebMCP tools registered on this page: onco_search, onco_get_entity.