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Mechlorethamine, or nitrogen mustard, was the first chemotherapy ever used, in 1940s Hodgkin lymphoma. Today its main use is as a skin gel (Valchlor in the US, Ledaga in Europe) for early cutaneous T-cell lymphoma.
Intravenous mechlorethamine (Mustargen, approved 1949) was the M in MOPP, the first curative combination chemotherapy for Hodgkin disease, and was labelled for Hodgkin and non-Hodgkin lymphomas, leukaemias, mycosis fungoides, bronchogenic carcinoma and malignant effusions; the intravenous product has been discontinued in the US. The 0.016% gel (Valchlor) was approved in August 2013 for stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma after prior skin-directed therapy, on a randomised observer-blinded trial (Study 201) against a compounded ointment; the EU authorised Ledaga in 2017 for the same indication. Contact dermatitis is the main adverse effect of the gel; the intravenous form was a potent vesicant and emetogen.
Bifunctional alkylating agent that forms interstrand DNA cross-links; the topical gel acts locally on malignant T cells in the skin.
1.Mechlorethamine (chlormethine) slips into a pocket on its target.
Compare all products across the US, EU, UK, Japan, China and Australia →
| Region | Year | Indication |
|---|---|---|
| US | 1949 | Hodgkin disease and other lymphomas, leukaemias, mycosis fungoides (intravenous; discontinued) |
| US | 2013 | Topical treatment of stage IA and IB mycosis fungoides-type CTCL after skin-directed therapy (Valchlor) |
| EU | 2017 | Topical treatment of mycosis fungoides-type CTCL (Ledaga) |
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Query for this drug: (TITLE:"Mechlorethamine" OR ABSTRACT:"Mechlorethamine" OR TITLE:"chlormethine" OR ABSTRACT:"chlormethine" OR TITLE:"Mustargen" OR ABSTRACT:"Mustargen" OR TITLE:"historic" OR ABSTRACT:"historic" OR TITLE:"Valchlor gel" OR ABSTRACT:"Valchlor gel" OR TITLE:"Nitrogen mustard" OR ABSTRACT:"Nitrogen mustard") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Mechlorethamine (chlormethine), not a curated reading list.
Shares Mycosis fungoides and the tag historic.
Shares Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome), Hodgkin lymphoma.
Shares Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares Mycosis fungoides, What the NHS in England funds for lymphoma, appraisal by appraisal, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).