Loading
Uvadex is the drug used in photopheresis, where a patient's white cells are drawn off, treated with methoxsalen and ultraviolet light, and returned; it is approved for the skin symptoms of cutaneous T-cell lymphoma and widely used for graft-versus-host disease.
Extracorporeal photopheresis was developed by Richard Edelson at Yale in the 1980s. The sterile methoxsalen solution Uvadex was approved by the FDA in 1999 for palliative treatment of the skin manifestations of cutaneous T-cell lymphoma unresponsive to other therapy, used with the THERAKOS photopheresis system. Responses occur in about half of patients with erythrodermic disease and Sézary syndrome, and the treatment is unusually well tolerated. Its largest use today is off label in steroid-refractory chronic graft-versus-host disease after stem cell transplantation and in transplant rejection. Oral methoxsalen has been used with UVA (PUVA) for psoriasis since the 1950s.
A psoralen that, when activated by UVA light, cross-links DNA in treated lymphocytes; reinfusing the damaged malignant T cells provokes an immune response against the clone.
1.Methoxsalen (extracorporeal photopheresis) slips into a pocket on its target.
| Region | Year | Indication |
|---|---|---|
| US | 1999 | Palliative treatment of skin manifestations of cutaneous T-cell lymphoma unresponsive to other therapy, by extracorporeal photopheresis |
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"Methoxsalen" OR ABSTRACT:"Methoxsalen" OR TITLE:"extracorporeal photopheresis" OR ABSTRACT:"extracorporeal photopheresis" OR TITLE:"Uvadex" OR ABSTRACT:"Uvadex" OR TITLE:"8-Methoxypsoralen" OR ABSTRACT:"8-Methoxypsoralen" OR TITLE:"8-MOP" OR ABSTRACT:"8-MOP") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Methoxsalen (extracorporeal photopheresis), not a curated reading list.
Shares Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome), Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma).
Shares Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares Extracorporeal Photopheresis and Mogamulizumab for the Treatment of Erythrodermic Cutaneous T Cell Lymphoma, Mycosis fungoides, Sezary syndrome, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Sezary syndrome, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Sezary syndrome, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares Mycosis fungoides, Sezary syndrome, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome), Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma).
Shares Sezary syndrome, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome), Peripheral T-cell lymphomas (including cutaneous T-cell lymphoma).