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Bexarotene (Targretin) is a vitamin A-like capsule and gel for the skin disease of cutaneous T-cell lymphoma when other treatments have stopped working.
Bexarotene is a synthetic retinoid selective for the retinoid X receptor. The FDA approved the capsules in December 1999 and the 1% gel in 2000 for cutaneous manifestations of cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome) refractory to at least one prior systemic therapy, on two open-label historically controlled trials in 152 patients. The EU authorised Targretin capsules in 2001 for the same population. Central hypothyroidism and marked hypertriglyceridaemia are expected effects of RXR activation and need thyroid replacement and lipid-lowering therapy alongside treatment; it is teratogenic.
Selectively binds and activates RXR alpha, beta and gamma; RXR heterodimers regulate transcription of genes controlling differentiation and apoptosis in malignant T cells. Connects to Retinoid X receptor (RXR).
1.Bexarotene acts on Retinoid X receptor (RXR), the hormone receptor or the enzyme that makes the hormone.
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| Region | Year | Indication |
|---|---|---|
| US | 1999 | Cutaneous manifestations of cutaneous T-cell lymphoma refractory to at least one systemic therapy |
| EU | 2001 | Skin manifestations of advanced-stage CTCL refractory to at least one systemic treatment |
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Query for this drug: (TITLE:"Bexarotene" OR ABSTRACT:"Bexarotene" OR TITLE:"Targretin" OR ABSTRACT:"Targretin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Bexarotene, not a curated reading list.
Shares Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares Vorinostat, Mycosis fungoides, Sezary syndrome, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares Vorinostat, Mycosis fungoides, Sezary syndrome, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares ALCANZA, Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Sezary syndrome.
Shares Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Sezary syndrome, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares ALCANZA, Mycosis fungoides, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).
Shares Skin-directed therapy in mycosis fungoides: creams, light and small radiotherapy fields, Mycosis fungoides, Cutaneous T-cell lymphoma (mycosis fungoides and Sezary syndrome).