Cancers & treatments·Regimen libraryCurative

MOPP

Checked 2026-09-09

Historical: the first curative combination chemotherapy for advanced Hodgkin lymphoma (1960s to 1980s), replaced by ABVD

One cycle

every 28 days × 6 · about 24 weeks in total

28-day cycle × 6 (about 24 weeks)IntravenousOral Daily oral course

Components

Drug	Dose	Route	Days
Mechlorethamine Alkylating agent (nitrogen mustard); intravenous and topical gel	6 mg/m²	IV	D1, 8
Vincristine Vinca alkaloid (microtubule inhibitor)	1.4 mg/m²	IV	D1, 8
Procarbazine Alkylating-like methylhydrazine derivative	100 mg/m² once daily	Oral	D1-14
Prednisone Glucocorticoid	40 mg/m² once daily	Oral	D1-14

Cycles

28-day cycle

Emetogenicity

High (>90%)

G-CSF

Not routine

Notes

Proof that combination chemotherapy could cure an advanced cancer; abandoned because of infertility and secondary leukaemia, which ABVD largely avoids.

Used in

Hodgkin lymphoma

Products

Mechlorethamine (chlormethine)VincristineProcarbazinePrednisone

Source

DeVita, Annals of Internal Medicine 1970: combination chemotherapy in advanced Hodgkin's disease

Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.