Cancers & treatments·Regimen libraryCurative

ABVD

Checked 2026-09-09

Classical Hodgkin lymphoma: 2-4 cycles early stage (PET-adapted), 6 cycles advanced stage

One cycle

every 28 days × 2-6 · about 8 weeks in total

28-day cycle × 2-6 (about 8 weeks)Intravenous

Components

Drug	Dose	Route	Days
Doxorubicin Cytotoxic chemotherapy (anthracycline)	25 mg/m²	IV	D1, 15
Bleomycin Glycopeptide antibiotic (DNA-cleaving)	10 units/m²	IV	D1, 15
Vinblastine Vinca alkaloid (microtubule inhibitor)	6 mg/m²	IV	D1, 15
Dacarbazine	375 mg/m²	IV	D1, 15

Cycles

2-6

28-day cycle

Emetogenicity

High (>90%)

G-CSF

Not routine

Notes

RATHL: drop bleomycin after a negative interim PET (AVD) with no loss of efficacy.
Give on schedule regardless of neutrophil count; G-CSF increases bleomycin lung toxicity.

Used in

Hodgkin lymphoma

Trials

RATHL

Products

DoxorubicinBleomycinVinblastine

Source

RATHL, NEJM 2016 (PET-adapted omission of bleomycin)

Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.