Cancers & treatments·Regimen libraryAdjuvant

FEC-100

Checked 2026-09-09

Adjuvant or neoadjuvant chemotherapy for early breast cancer, usually 3 cycles followed by 3 cycles of docetaxel (FEC-T)

Also called FEC, FEC100.

One cycle

every 21 days × 3-6 · about 9 weeks in total

21-day cycle × 3-6 (about 9 weeks)Intravenous

Components

Drug	Dose	Route	Days
Fluorouracil Fluoropyrimidine antimetabolite	500 mg/m²	IV	D1
Epirubicin Anthracycline (topoisomerase II inhibitor)	100 mg/m²	IV	D1
Cyclophosphamide Alkylating agent (oxazaphosphorine prodrug)	500 mg/m²	IV	D1

Cycles

3-6

21-day cycle

Emetogenicity

High (>90%)

G-CSF

Consider (10-20% FN risk)

Notes

Epirubicin cumulative dose limits apply; check LVEF.
Fluorouracil adds little in modern anthracycline-taxane sequences and is omitted in EC-T schedules.

Used in

HR-positive / HER2-negative breast cancer HER2-positive breast cancer Triple-negative breast cancer (TNBC)

Products

Fluorouracil (5-FU)EpirubicinCyclophosphamide

Source

French Adjuvant Study Group (FASG 05), JCO 2001: FEC 100 versus FEC 50

Reference doses for a typical adult from the cited protocol or label. Doses are adjusted for renal and hepatic function, age, performance status and prior toxicity, and institutional protocols vary. Verify against the current label and your local protocol before treating. Not medical advice.