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Icotinib, approved in 2011, was the first cancer drug invented and developed in China, and it showed that a domestic lung cancer pill could match a Western one head to head.
Betta Pharmaceuticals' icotinib was approved by the then SFDA in June 2011 for advanced NSCLC after chemotherapy, on the ICOGEN trial that showed non-inferiority to gefitinib (Lancet Oncology 2013). First-line EGFR-mutant approval followed in 2014, and the EVIDENCE trial (Lancet Respiratory Medicine 2021) supported adjuvant use after resection of stage II to IIIA EGFR-mutant disease. It was the first drug in the 2016 pilot of national price negotiation, taking a large cut to enter reimbursement, the template for the later NRDL rounds.
Reversible ATP-competitive inhibitor of EGFR tyrosine kinase, structurally related to erlotinib. Connects to EGFR.
1.Icotinib slips into a pocket on EGFR.
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| Region | Year | Indication |
|---|---|---|
| China | 2011 | Advanced NSCLC after failure of at least one chemotherapy regimen (ICOGEN) |
| China | 2014 | First-line EGFR-mutant NSCLC |
| China | 2021 | Adjuvant treatment of resected stage II to IIIA EGFR-mutant NSCLC (EVIDENCE) |
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Query for this drug: (TITLE:"Icotinib" OR ABSTRACT:"Icotinib" OR TITLE:"Conmana" OR ABSTRACT:"Conmana" OR TITLE:"BPI-2009H" OR ABSTRACT:"BPI-2009H") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Icotinib, not a curated reading list.
Shares EGFR, Small-molecule kinase inhibitors, Non-small-cell lung cancer and the tag china.
Shares RAS / RAF / MEK / ERK (MAPK), EGFR, Small-molecule kinase inhibitors, Non-small-cell lung cancer and the tag china.
Shares EGFR, Small-molecule kinase inhibitors, Non-small-cell lung cancer and the tag china.
Shares RAS / RAF / MEK / ERK (MAPK), Small-molecule kinase inhibitors, Non-small-cell lung cancer and the tag china.
Shares RAS / RAF / MEK / ERK (MAPK), EGFR, Small-molecule kinase inhibitors, Non-small-cell lung cancer and the tag china.
Shares Small-molecule kinase inhibitors, Non-small-cell lung cancer and the tag china.
Shares RAS / RAF / MEK / ERK (MAPK), Small-molecule kinase inhibitors, Non-small-cell lung cancer and the tag china.
Shares Betta Pharmaceuticals and the tag china.