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Garsorasib is InventisBio's KRAS G12C-blocking pill, approved in China in 2024 for previously treated lung cancer with that mutation.
Approved by the NMPA in August 2024 for KRAS G12C-mutant advanced NSCLC after prior systemic therapy, on a single-arm phase 2 trial that followed the phase 1 study published in the Journal of Thoracic Oncology in 2023. With fulzerasib it made China the second market with domestic KRAS G12C inhibitors; combination studies with EGFR antibodies and SHP2 inhibitors are under way.
Covalent KRAS G12C inhibitor binding the switch II pocket of the GDP-bound mutant protein. Connects to KRAS.
1.Garsorasib slips into a pocket on KRAS.
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| Region | Year | Indication |
|---|---|---|
| China | 2024 | KRAS G12C-mutant advanced NSCLC after at least one systemic therapy |
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Query for this drug: (TITLE:"Garsorasib" OR ABSTRACT:"Garsorasib" OR TITLE:"D-1553" OR ABSTRACT:"D-1553") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Garsorasib, not a curated reading list.
Shares A Trial of HRS-7058 in Advanced or Metastatic Non-Small Cell Lung Cancer Patients Who Have Failed Standard Treatment, KRAS mutation subtypes (G12C, G12D, G12V), KRAS & RAS inhibitors, RAS / RAF / MEK / ERK (MAPK) and the tag china.
Shares RAS / RAF / MEK / ERK (MAPK), Small-molecule kinase inhibitors, Non-small-cell lung cancer and the tag china.
Shares RAS / RAF / MEK / ERK (MAPK), Small-molecule kinase inhibitors, Non-small-cell lung cancer and the tag china.
Shares Small-molecule kinase inhibitors, Non-small-cell lung cancer and the tag china.
Shares RAS / RAF / MEK / ERK (MAPK), Small-molecule kinase inhibitors and the tag china.
Shares Small-molecule kinase inhibitors, Non-small-cell lung cancer and the tag china.
Shares InventisBio and the tag china.
Shares RAS / RAF / MEK / ERK (MAPK), Small-molecule kinase inhibitors, Non-small-cell lung cancer and the tag china.