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CD38 is on almost every myeloma cell, so daratumumab and isatuximab are given without testing for it. The stain matters afterwards: CD38 falls after treatment and can confuse flow cytometry and blood typing.
Daratumumab and isatuximab are CD38-directed antibodies labelled for multiple myeloma by line of therapy, not by CD38 level; every label describes the antigen only in the mechanism section. CD38 expression is near-universal on plasma cells and drops for months after anti-CD38 therapy, which is why laboratories use alternative gating in flow cytometry and why the drugs interfere with indirect antiglobulin tests.
In plain words · CD38 is a myeloma surface enzyme and the target of daratumumab, which is now given as a quick under-the-skin injection.
You will not usually be tested for CD38 before daratumumab or isatuximab; the antigen is present on virtually all myeloma cells. Tell any hospital laboratory you are on an anti-CD38 antibody, because it interferes with blood-matching tests for transfusion.
Written only from the label or guideline text cited on this page. Not medical advice; your own report and the reading your team gives it come first.
The label names the antigen in the drug's description but does not require it to be measured before treatment; no approval threshold exists for this readout.
“DARZALEX is a CD38-directed cytolytic antibody”
DARZALEX prescribing information (DailyMed)No approval uses this readout as a threshold.
Matched on the name and aliases of the readout in the title, setting and summary of each trial; a match is a mention, not proof the readout was an entry criterion.
Shares GPRC5D expression, BCMA expression, Relapsed or refractory multiple myeloma, Multiple myeloma and the tags biomarker, surface-antigen, no-threshold.
Shares the tags biomarker, surface-antigen, no-threshold.
Shares the tags biomarker, surface-antigen, no-threshold.
Shares the tags biomarker, surface-antigen, no-threshold.
Shares the tags biomarker, surface-antigen, no-threshold.
Shares the tags biomarker, surface-antigen, no-threshold.
Shares the tags biomarker, surface-antigen, no-threshold.
Shares the tags biomarker, surface-antigen, no-threshold.