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DLL3 sits on the surface of about 85 percent of small-cell lung cancers and almost no normal adult tissue. Tarlatamab is given without a DLL3 test.
Tarlatamab (Imdelltra) is a DLL3 x CD3 bispecific labelled for extensive-stage small-cell lung cancer after platinum chemotherapy; the DeLLphi trials enrolled without DLL3 selection and the label names DLL3 only as the target. DLL3-directed ADCs, radioligands and CAR-T cells in trials likewise do not gate on expression, and a DLL3 PET tracer is under study.
In plain words · A protein that appears on the surface of small-cell lung cancer cells, now hit by a drug that pulls T cells onto them.
Tarlatamab does not require a DLL3 test; the target is present in most small-cell lung cancers. Treatment starts in hospital because of the risk of cytokine release in the first cycle.
Written only from the label or guideline text cited on this page. Not medical advice; your own report and the reading your team gives it come first.
The label names the antigen in the drug's description but does not require it to be measured before treatment; no approval threshold exists for this readout.
“IMDELLTRA is a bispecific delta-like ligand 3 (DLL3)-directed CD3 T-cell engager”
IMDELLTRA prescribing information (DailyMed)No approval uses this readout as a threshold.
Matched on the name and aliases of the readout in the title, setting and summary of each trial; a match is a mention, not proof the readout was an entry criterion.
It is the reality check on the subtype model and it has a direct consequence for treatment: the DLL3-directed medicines are aimed at the neuroendocrine-high subtypes, and the POU2F3 and double-negative tumours will not express the target.
The organising framework for every small-cell lung cancer trial designed since. It is also why the slow progress in the disease is now attributed to treating four diseases as one rather than to the biology being intractable.
Shares the tags biomarker, surface-antigen, no-threshold.
Shares the tags biomarker, surface-antigen, no-threshold.
Shares the tags biomarker, surface-antigen, no-threshold.
Shares the tags biomarker, surface-antigen, no-threshold.
Shares the tags biomarker, surface-antigen, no-threshold.
Shares the tags biomarker, surface-antigen, no-threshold.
Shares the tags biomarker, surface-antigen, no-threshold.
Shares the tags biomarker, surface-antigen, no-threshold.