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Trials
Adaptive Phase 1/2 Study of Dual-Target CAR-NK Cells in Relapsed/Refractory Small Cell Lung Cancer (SCLC)

trialsTrialRecruiting

Adaptive Phase 1/2 Study of Dual-Target CAR-NK Cells in Relapsed/Refractory Small Cell Lung Cancer (SCLC)

A phase 1/2 trial of EB-DART-NK01 (DLL3/CD56 CAR-NK cells) in small-cell lung cancer, run by Beijing Biotech, now recruiting.

Also called: DART-NK-SCLC

Overview Connected3

Overview

Adaptive Phase 1/2 Study of Dual-Target CAR-NK Cells in Relapsed/Refractory Small Cell Lung Cancer (SCLC) is a phase 1/2 interventional study registered as NCT07480213 by Beijing Biotech, with 60 participants planned, started 2026-02-02 and due to reach its primary completion in 2027-02-14. Interventions recorded: EB-DART-NK01 (DLL3/CD56 CAR-NK cells) and Lymphodepleting chemotherapy.

Setting

A Phase 1/2 Adaptive Dose-Escalation and Expansion Study of Dual-Targeting Chimeric Antigen Receptor Natural Killer (CAR-NK) Cells Directed Against DLL3, CD56 (NCAM1), and/or GD2 in Adults With Relapsed/Refractory Small Cell Lung Cancer

Phase

Phase 1/2

Sponsor

Beijing Biotech

Registry

Started

2026-02-02

Enrolled

60 enrolled

Connected

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cancers

Small-cell lung cancer

targets

DLL3 GD2 (disialoganglioside)

Evidence strength17/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
60 enrolled+9
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-18 · Jude Gomila · Add 115 registry trial acronyms from the CT.gov acronym f… · diff · file

Sources & links

ClinicalTrials.gov NCT07480213

Data

JSON ·

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Cancers

Small-cell lung cancer

Targets

GD2 (disialoganglioside)
DLL3

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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