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Trials
HRS-4642 Combination With Other Antitumor Therapies in Patients With Solid Tumors

trialsTrialRecruiting

HRS-4642 Combination With Other Antitumor Therapies in Patients With Solid Tumors

A phase 1/2 trial of Adebrelimab and Gemcitabine in pancreatic ductal adenocarcinoma, run by Shanghai Hengrui Pharmaceutical Co., Ltd., now recruiting.

Overview Connected4

Overview

HRS-4642 Combination With Other Antitumor Therapies in Patients With Solid Tumors is a phase 1/2 interventional study registered as NCT07296341 by Shanghai Hengrui Pharmaceutical Co., Ltd., with 60 participants planned, started 2026-01-08 and due to reach its primary completion in 2027-10. Interventions recorded: HRS-4642;Adebrelimab Injection; nab-paclitaxel; gemcitabine and HRS-4642;nab-paclitaxel; gemcitabine.

Setting

A Phase IB/II Study To Evaluate the Safety, Tolerability, and Preliminary Efficacy of HRS-4642 Combination With Other Antitumor Therapies in Patients With Solid Tumors

Phase

Phase 1/2

Sponsor

Shanghai Hengrui Pharmaceutical Co., Ltd.

Registry

Started

2026-01-08

Enrolled

60 enrolled

Connected

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cancers

Pancreatic ductal adenocarcinoma

drugs

ApprovedMonoclonal antibody (anti-PD-L1, humanised IgG4)

Adebrelimab · Arelili

ApprovedNucleoside analogue (deoxycytidine)

Gemcitabine · Gemzar / Infugem

companies

Jiangsu Hengrui Pharmaceuticals

Evidence strength22/100 · Preliminary

How much and what kind of evidence, not how big the benefit. Click for the breakdown.

Phase 1/2+8
60 enrolled+9
No structured primary endpoint0
Result: recruiting0
No independent replication recorded0
A linked product is approved+5

Formula disclosed on the evidence page.

ProvenanceLast edited 2026-09-16 · Jude Gomila · Registry trials wave 6 and products wave 7 · diff · file

Sources & links

ClinicalTrials.gov NCT07296341

Data

JSON ·

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Cancers

Pancreatic ductal adenocarcinoma

Products

Adebrelimab
Gemcitabine

Companies

Jiangsu Hengrui Pharmaceuticals

Not yet reviewedNeeds expert (clinical) review. Review this page or see the review queue and roster.

Model panel commentary is coming to this page: machine commentary, not clinical review.

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